Anti-HTATIP2 Antibody (CAB5816)
- SKU:
- CAB5816
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| Antibody Name: | Anti-HTATIP2 Antibody |
| Antibody SKU: | CAB5816 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human HTATIP2 (NP_006401.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | LO2 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human HTATIP2 (NP_006401.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GAEG FVRV DRDY VLKS AELA KAGG CKHF NLLS SKGA DKSS NFLY LQVK GEVE AKVE ELKF DRYS VFRP GVLL CDRQ ESRP GEWL VRKF FGSL PDSW ASGH SVPV VTVV RAML NNVV RPRD KQME LLEN KAIH DLGK AHGS LKP |
| Gene ID: | 10553 |
| Uniprot: | Q9BUP3 |
| Cellular Location: | Cytoplasm, Nucleus envelope |
| Calculated MW: | 14kDa/27kDa/30kDa |
| Observed MW: | 27kDa |
| Synonyms: | HTATIP2, CC3, SDR44U1, TIP30 |
| Background: |
| UniProt Protein Function: | HTATIP2: Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oxidoreductase; Apoptosis; Tumor suppressor; Nuclear envelope; Transcription factor; EC 1.1.1.- Chromosomal Location of Human Ortholog: 11p15.1 Cellular Component: membrane; cytoplasm; nuclear envelope; nucleus Molecular Function:protein binding; transcription coactivator activity; oxidoreductase activity Biological Process: regulation of transcription from RNA polymerase II promoter; viral reproduction; apoptosis; nuclear import; angiogenesis; cell differentiation; regulation of angiogenesis; negative regulation of apoptosis |
| UniProt Code: | Q9BUP3 |
| NCBI GenInfo Identifier: | 317373366 |
| NCBI Gene ID: | 10553 |
| NCBI Accession: | Q9BUP3.2 |
| UniProt Secondary Accession: | Q9BUP3,O15383, O60520, O95345, Q53GC1, Q53GG2, Q6IBI3 A8K7S7, D3DQY8, |
| UniProt Related Accession: | Q9BUP3 |
| Molecular Weight: | 242 |
| NCBI Full Name: | Oxidoreductase HTATIP2 |
| NCBI Synonym Full Names: | HIV-1 Tat interactive protein 2, 30kDa |
| NCBI Official Symbol: | HTATIP2 |
| NCBI Official Synonym Symbols: | CC3; TIP30; SDR44U1 |
| NCBI Protein Information: | oxidoreductase HTATIP2; Tat-interacting protein (30kD); HIV-1 TAT-interactive protein 2; 30 kDa HIV-1 TAT-interacting protein; short chain dehydrogenase/reductase family 44U, member 1 |
| UniProt Protein Name: | Oxidoreductase HTATIP2 |
| UniProt Synonym Protein Names: | 30 kDa HIV-1 TAT-interacting protein; HIV-1 TAT-interactive protein 2 |
| Protein Family: | Oxidoreductase |
| UniProt Gene Name: | HTATIP2 |
| UniProt Entry Name: | HTAI2_HUMAN |
 | Western blot analysis of extracts of LO2 cells, using HTATIP2 antibody (CAB5816) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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