Anti-HAUS3 Antibody (CAB8258)

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SKU:
CAB8258
Product type:
Antibody
Application:
WB
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle
Frequently bought together:

Description

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Antibody Name:HAUS3 Rabbit Polyclonal Antibody
Antibody SKU:CAB8258
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 384-603 of human HAUS3 (NP_078787.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, HeLa, A-549, Mouse heart, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 384-603 of human HAUS3 (NP_078787.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FELL QLSY EIEL RKHR DIYR QLEN LVQE LSQS NMML YKQL EMLT DPSV SQQI NPRN TIDT KDYS THRL YQVL EGEN KKKE LFLT HGNL EEVA EKLK QNIS LVQD QLAV SAQE HSFF LSKR NKDV DMLC DTLY QGGN QLLL SDQE LTEQ FHKV ESQL NKLN HLLT DILA DVKT KRKT LANN KLHQ MERE FYVY FLKD EDYL KDIV ENLE TQSK IKAV SLED
Gene ID:79441
Uniprot:Q68CZ6
Cellular Location:Cytoplasm, centrosome, cytoskeleton, microtubule organizing center, spindle
Calculated MW:56kDa/69kDa
Observed MW:80kDa
Synonyms:HAUS3, C4orf15, IT1, dgt3
Background:This gene encodes a component of the HAUS augmin-like protein complex, which plays a key role in cytokinesis and mitosis. Disruption of the encoded protein causes mitotic defects resulting from fragmentation of centrosomes and microtubule destabilization. This gene shares its 5' exons with some transcripts from overlapping GeneID: 353497, which encodes a DNA polymerase. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:HAUS3: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Belongs to the HAUS3 family.
UniProt Protein Details:

Protein type:Cell cycle regulation; Cytoskeletal

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: centrosome; cytosol; microtubule cytoskeleton; mitochondrion; nucleoplasm

Molecular Function:protein binding

Biological Process: centrosome organization and biogenesis; G2/M transition of mitotic cell cycle; spindle assembly

NCBI Summary:This gene encodes a component of the HAUS augmin-like protein complex, which plays a key role in cytokinesis and mitosis. Disruption of the encoded protein causes mitotic defects resulting from fragmentation of centrosomes and microtubule destabilization. This gene shares its 5' exons with some transcripts from overlapping GeneID: 353497, which encodes a DNA polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
UniProt Code:Q68CZ6
NCBI GenInfo Identifier:74708788
NCBI Gene ID:79441
NCBI Accession:Q68CZ6.1
UniProt Secondary Accession:Q68CZ6,O43606, Q8TAZ5, Q9BTJ9, B4DF64,
UniProt Related Accession:Q68CZ6
Molecular Weight:56,384 Da
NCBI Full Name:HAUS augmin-like complex subunit 3
NCBI Synonym Full Names:HAUS augmin like complex subunit 3
NCBI Official Symbol:HAUS3  
NCBI Official Synonym Symbols:IT1; dgt3; C4orf15  
NCBI Protein Information:HAUS augmin-like complex subunit 3
UniProt Protein Name:HAUS augmin-like complex subunit 3
Protein Family:HAUS augmin-like complex
UniProt Gene Name:HAUS3  
UniProt Entry Name:HAUS3_HUMAN
Anti-HAUS3 Polyclonal Antibody (CAB8258)Western blot analysis of extracts of various cell lines, using HAUS3 antibody (CAB8258) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.

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