Anti-GULP1 Antibody (CAB3432)
- SKU:
- CAB3432
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-GULP1 Antibody |
| Antibody SKU: | CAB3432 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human GULP1 (NP_057399.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, 293T, Mouse lung, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human GULP1 (NP_057399.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNRA FSRK KDKT WMHT PEAL SKHF IPYN AKFL GSTE VEQP KGTE VVRD AVRK LKFA RHIK KSEG QKIP KVEL QISI YGVK ILEP KTKE VQHN CQLH RISF CADD KTDK RIFT FICK DSES NKHL CYVF DS |
| Gene ID: | 51454 |
| Uniprot: | Q9UBP9 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 19kDa/22kDa/33kDa/34kDa |
| Observed MW: | 34kDa |
| Synonyms: | GULP1, CED-6, CED6, GULP |
| Background: | The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. |
| UniProt Protein Function: | GULP1: May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. Belongs to the ced-6 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 2q32.3-q33 Cellular Component: cytoplasm Molecular Function:signal transducer activity Biological Process: apoptosis; phagocytosis, engulfment; lipid transport; signal transduction |
| NCBI Summary: | The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q9UBP9 |
| NCBI GenInfo Identifier: | 74720076 |
| NCBI Gene ID: | 51454 |
| NCBI Accession: | Q9UBP9.1 |
| UniProt Secondary Accession: | Q9UBP9,Q53PC1, Q53RF3, Q9BVL3, B2RB51, B4DQ40, B8ZZ72 D3DPH1, E9PB86, |
| UniProt Related Accession: | Q9UBP9 |
| Molecular Weight: | 304 |
| NCBI Full Name: | PTB domain-containing engulfment adapter protein 1 |
| NCBI Synonym Full Names: | GULP, engulfment adaptor PTB domain containing 1 |
| NCBI Official Symbol: | GULP1 |
| NCBI Official Synonym Symbols: | CED6; GULP; CED-6 |
| NCBI Protein Information: | PTB domain-containing engulfment adapter protein 1; cell death protein 6 homolog; PTB domain adapter protein CED-6; PTB domain adaptor protein CED-6 |
| UniProt Protein Name: | PTB domain-containing engulfment adapter protein 1 |
| UniProt Synonym Protein Names: | Cell death protein 6 homolog; PTB domain adapter protein CED-6; Protein GULP |
| Protein Family: | PTB domain-containing engulfment adapter protein |
| UniProt Gene Name: | GULP1 |
| UniProt Entry Name: | GULP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GULP1 antibody (CAB3432) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded Mouse spinal cord using GULP1 Rabbit pAb (CAB3432) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Rat ovary using GULP1 Rabbit pAb (CAB3432) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Human colon carcinoma using GULP1 Rabbit pAb (CAB3432) at dilution of 1:100 (40x lens). |
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