Anti-GUCA2B Antibody (CAB8390)
- SKU:
- CAB8390
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-GUCA2B Antibody |
| Antibody SKU: | CAB8390 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GUCA2B (NP_009033.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse intestine |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GUCA2B (NP_009033.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGCR AASG LLPG VAVV LLLL LQST QSVY IQYQ GFRV QLES MKKL SDLE AQWA PSPR LQAQ SLLP AVCH HPAL PQDL QPVC ASQE ASSI FKTL RTIA NDDC |
| Gene ID: | 2981 |
| Uniprot: | Q16661 |
| Cellular Location: | Secreted |
| Calculated MW: | 12kDa |
| Observed MW: | 12kDa |
| Synonyms: | GUCA2B, GCAP-II, UGN |
| Background: | This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys. |
| UniProt Protein Function: | GUCA2B: Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. Belongs to the guanylin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1p34-p33 Molecular Function:calcium sensitive guanylate cyclase activator activity |
| NCBI Summary: | This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys. [provided by RefSeq, Nov 2015] |
| UniProt Code: | Q16661 |
| NCBI GenInfo Identifier: | 2495130 |
| NCBI Gene ID: | 2981 |
| NCBI Accession: | Q16661.1 |
| UniProt Secondary Accession: | Q16661,Q52LV0, |
| UniProt Related Accession: | Q16661 |
| Molecular Weight: | 12,069 Da |
| NCBI Full Name: | Guanylate cyclase activator 2B |
| NCBI Synonym Full Names: | guanylate cyclase activator 2B |
| NCBI Official Symbol: | GUCA2B |
| NCBI Official Synonym Symbols: | UGN; GCAP-II |
| NCBI Protein Information: | guanylate cyclase activator 2B |
| UniProt Protein Name: | Guanylate cyclase activator 2B |
| UniProt Synonym Protein Names: | Guanylate cyclase C-activating peptide 2Alternative name(s):Guanylate cyclase C-activating peptide II; GCAP-II |
| Protein Family: | Guanylate cyclase activator |
| UniProt Gene Name: | GUCA2B |
| UniProt Entry Name: | GUC2B_HUMAN |
 | Western blot analysis of extracts of mouse small intestine, using GUCA2B antibody (CAB8390) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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