Anti-GNA11 Antibody (CAB2731)
- SKU:
- CAB2731
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-GNA11 Antibody |
| Antibody SKU: | CAB2731 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human GNA11 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BT-474, SKOV3, Mouse brain, Mouse kidney, Mouse lung, Mouse intestine |
| Immunogen: | Recombinant protein of human GNA11 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2767 |
| Uniprot: | P29992 |
| Cellular Location: | Cell membrane, Cytoplasm, Lipid-anchor |
| Calculated MW: | 42kDa |
| Observed MW: | 42kDa |
| Synonyms: | GNA11, FBH, FBH2, FHH2, GNA-11, HHC2, HYPOC2 |
| Background: | The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. |
| UniProt Protein Function: | G-alpha 11: a guanine nucleotide-binding protein of the G-alpha family. Acts as an activator of phospholipase C. Involved in signaling of gonadotropin-releasing hormone receptor, negatively regulating cell growth. Down-regulation may be involved in human breast cancers. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. |
| UniProt Protein Details: | Protein type:G protein, heterotrimeric; G protein; G protein, heterotrimeric alpha G(q) Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: lysosomal membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex Molecular Function:GTPase activity; signal transducer activity; GTP binding; type 2A serotonin receptor binding; metal ion binding; G-protein beta/gamma-subunit binding Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; regulation of action potential; platelet activation; metabolic process; heart development; pigmentation during development; dopamine receptor, phospholipase C activating pathway; signal transduction; blood coagulation; skeletal development; regulation of melanocyte differentiation Disease: Hypocalciuric Hypercalcemia, Familial, Type Ii |
| NCBI Summary: | The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013] |
| UniProt Code: | P29992 |
| NCBI GenInfo Identifier: | 3041682 |
| NCBI Gene ID: | 2767 |
| NCBI Accession: | P29992.2 |
| UniProt Related Accession: | P29992 |
| Molecular Weight: | ~42kDa |
| NCBI Full Name: | Guanine nucleotide-binding protein subunit alpha-11 |
| NCBI Synonym Full Names: | G protein subunit alpha 11 |
| NCBI Official Symbol: | GNA11 |
| NCBI Official Synonym Symbols: | FBH; FBH2; FHH2; HHC2; GNA-11; HYPOC2 |
| NCBI Protein Information: | guanine nucleotide-binding protein subunit alpha-11 |
| UniProt Protein Name: | Guanine nucleotide-binding protein subunit alpha-11 |
| UniProt Synonym Protein Names: | Guanine nucleotide-binding protein G(y) subunit alpha |
| Protein Family: | Guanine nucleotide-binding protein |
| UniProt Gene Name: | GNA11 |
| UniProt Entry Name: | GNA11_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GNA11 antibody (CAB2731) at 1:400 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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