Anti-GIPR 항체 (CAB9816)

Antibody Name:	Anti-GIPR Antibody
Antibody SKU:	CAB9816
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 22-138 of human GIPR (NP_000155.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	K-562, Mouse liver, Rat heart, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 22-138 of human GIPR (NP_000155.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	RAET GSKG QTAG ELYQ RWER YRRE CQET LAAA EPPS GLAC NGSF DMYV CWDY AAPN ATAR ASCP WYLP WHHH VAAG FVLR QCGS DGQW GLWR DHTQ CENP EKNE AFLD QRLI LERL Q
Gene ID:	2696
Uniprot:	P48546
Cellular Location:	Cell membrane, Multi-pass membrane protein
Calculated MW:	48kDa/49kDa/53kDa
Observed MW:	45kDa

Synonyms:

GIPR, PGQTL2

Background:

This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.

UniProt Protein Function:	GIPR: This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral; Receptor, GPCR Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: plasma membrane Molecular Function:transmembrane receptor activity Biological Process: adenylate cyclase activation; generation of precursor metabolites and energy; regulation of insulin secretion; response to nutrient
NCBI Summary:	This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]
UniProt Code:	P48546
NCBI GenInfo Identifier:	1346133
NCBI Gene ID:	2696
NCBI Accession:	P48546.1
UniProt Secondary Accession:	P48546,Q14401, Q16400, Q52M04, Q9UPI1, B7WP14, B7ZKQ0
UniProt Related Accession:	P48546
Molecular Weight:	49,062 Da
NCBI Full Name:	Gastric inhibitory polypeptide receptor
NCBI Synonym Full Names:	gastric inhibitory polypeptide receptor
NCBI Official Symbol:	GIPR
NCBI Official Synonym Symbols:	PGQTL2
NCBI Protein Information:	gastric inhibitory polypeptide receptor
UniProt Protein Name:	Gastric inhibitory polypeptide receptor
UniProt Synonym Protein Names:	Glucose-dependent insulinotropic polypeptide receptor
Protein Family:	Gastric inhibitory polypeptide receptor
UniProt Gene Name:	GIPR
UniProt Entry Name:	GIPR_HUMAN

	Western blot analysis of extracts of various cell lines, using GIPR antibody (CAB9816) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded rat brain using GIPR Rabbit pAb (CAB9816) at dilution of 1:200 (40x lens).

Antibodies	ELISA Kits
GIPR Antibody (PACO00854)	Human Gastric inhibitory polypeptide receptor (GIPR) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)