Anti-GCGR Antibody (CAB10617)
- SKU:
- CAB10617
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| Antibody Name: | Anti-GCGR Antibody |
| Antibody SKU: | CAB10617 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human GCGR (NP_000151.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human GCGR (NP_000151.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPPC QPQR PLLL LLLL LACQ PQVP SAQV MDFL FEKW KLYG DQCH HNLS LLPP PTEL VCNR TFDK YSCW PDTP ANTT ANIS CPWY LPWH HKVQ HRFV FKRC GPDG QWVR GPRG QPWR DASQ CQMD GEEI EVQK EVAK MYSS |
| Gene ID: | 2642 |
| Uniprot: | P47871 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 54kDa |
| Observed MW: | Refer to figures |
| Synonyms: | GCGR, GGR, GL-R |
| Background: | The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM). |
| UniProt Protein Function: | GCGR: This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral; Receptor, GPCR Chromosomal Location of Human Ortholog: 17q25 Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane Molecular Function:glucagon receptor activity; guanyl-nucleotide exchange factor activity Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; generation of precursor metabolites and energy; glucose homeostasis; regulation of blood pressure; response to nutrient; response to starvation Disease: Diabetes Mellitus, Noninsulin-dependent |
| NCBI Summary: | The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010] |
| UniProt Code: | P47871 |
| NCBI GenInfo Identifier: | 1346144 |
| NCBI Gene ID: | 2642 |
| NCBI Accession: | P47871.1 |
| UniProt Secondary Accession: | P47871,Q2M3M5, |
| UniProt Related Accession: | P47871 |
| Molecular Weight: | 54,009 Da |
| NCBI Full Name: | Glucagon receptor |
| NCBI Synonym Full Names: | glucagon receptor |
| NCBI Official Symbol: | GCGR |
| NCBI Official Synonym Symbols: | GGR; GL-R |
| NCBI Protein Information: | glucagon receptor |
| UniProt Protein Name: | Glucagon receptor |
| Protein Family: | Glucagon receptor |
| UniProt Gene Name: | GCGR |
| UniProt Entry Name: | GLR_HUMAN |
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