Anti-Gamma-crystallin C Antibody (CAB9324)

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SKU:
CAB9324
Product type:
Antibody
Application:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-Gamma-crystallin C Antibody
Antibody SKU:CAB9324
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-174 of human CRYGC (NP_066269.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human
Positive Samples:MCF7, U-251MG
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-174 of human CRYGC (NP_066269.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGKI TFYE DRAF QGRS YETT TDCP NLQP YFSR CNSI RVES GCWM LYER PNYQ GQQY LLRR GEYP DYQQ WMGL SDSI RSCC LIPQ TVSH RLRL YERE DHKG LMME LSED CPSI QDRF HLSE IRSL HVLE GCWV LYEL PNYR GRQY LLRP QEYR RCQD WGAM DAKA GSLR RVVD LY
Gene ID:1420
Uniprot:P07315
Cellular Location:
Calculated MW:20kDa
Observed MW:17kDa
Synonyms:CRYGC, CCL, CRYG3, CTRCT2
Background:This gene encodes a member of the beta/gamma-crystallin family of proteins. Crystallins constitute the major proteins of vertebrate eye lens and maintain the transparency and refractive index of the lens. This gene and several family members are present in a gene cluster on chromosome 2. Mutations in this gene have been shown to cause multiple types of cataract, including Coppock-like cataract and zonular pulverulent cataract, among others.
UniProt Protein Function:CRYGC: a major structural protein of the eye lens. A member of the beta/gamma-crystallin family. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. Gamma-crystallins are involved in cataract formation.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 2q33.3

Cellular Component: cytoplasm; nucleus

Molecular Function:protein binding; structural constituent of eye lens

Biological Process: camera-type eye development; visual perception

Disease: Cataract 2, Multiple Types

NCBI Summary:This gene encodes a member of the beta/gamma-crystallin family of proteins. Crystallins constitute the major proteins of vertebrate eye lens and maintain the transparency and refractive index of the lens. This gene and several family members are present in a gene cluster on chromosome 2. Mutations in this gene have been shown to cause multiple types of cataract, including Coppock-like cataract and zonular pulverulent cataract, among others. [provided by RefSeq, Jan 2015]
UniProt Code:P07315
NCBI GenInfo Identifier:10518338
NCBI Gene ID:1420
NCBI Accession:NP_066269
UniProt Secondary Accession:P07315,Q53R50,
UniProt Related Accession:P07315
Molecular Weight:23.5kDa (198aa), confirmed by MALDI-TOF
NCBI Full Name:gamma-crystallin C
NCBI Synonym Full Names:crystallin gamma C
NCBI Official Symbol:CRYGC  
NCBI Official Synonym Symbols:CCL; CRYG3; CTRCT2  
NCBI Protein Information:gamma-crystallin C
UniProt Protein Name:Gamma-crystallin C
UniProt Synonym Protein Names:Gamma-C-crystallin; Gamma-crystallin 2-1; Gamma-crystallin 3
Protein Family:Gamma-crystallin
UniProt Gene Name:CRYGC  
UniProt Entry Name:CRGC_HUMAN
Anti-Gamma-crystallin C Polyclonal Antibody (CAB9324)Western blot analysis of extracts of various cell lines, using CRYGC antibody (CAB9324) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.

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