Anti-GALP Antibody (CAB17445)
- SKU:
- CAB17445
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-GALP Antibody |
| Antibody SKU: | CAB17445 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-116 of human GALP (NP_149097.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-116 of human GALP (NP_149097.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | APAH RGRG GWTL NSAG YLLG PVLH LPQM GDQD GKRE TALE ILDL WKAI DGLP YSHP PQPS KRNV METF AKPE IGDL GMLS MKIP KEED VLKS |
| Gene ID: | 85569 |
| Uniprot: | Q9UBC7 |
| Cellular Location: | |
| Calculated MW: | 13kDa |
| Observed MW: | 20kDa |
| Synonyms: | GALP |
| Background: | This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors. |
| UniProt Protein Function: | GALP: Hypothalamic neuropeptide which binds to the G-protein- coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin- releasing hormone secretion. Isoform 2 exhibits potent and dose- dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2. Belongs to the galanin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 19q13.43 Cellular Component: extracellular region Molecular Function:hormone activity Biological Process: neuropeptide signaling pathway; behavioral response to starvation; defense response to bacterium; regulation of appetite; response to insulin stimulus |
| NCBI Summary: | This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, may have vasoactive properties and serve as a marker for neuroblastic tumors.[provided by RefSeq, Mar 2009] |
| UniProt Code: | Q9UBC7 |
| NCBI GenInfo Identifier: | 20138432 |
| NCBI Gene ID: | 85569 |
| NCBI Accession: | Q9UBC7.1 |
| UniProt Secondary Accession: | Q9UBC7,A1KXL3, |
| UniProt Related Accession: | Q9UBC7 |
| Molecular Weight: | 5,321 Da |
| NCBI Full Name: | Galanin-like peptide |
| NCBI Synonym Full Names: | galanin-like peptide |
| NCBI Official Symbol: | GALP |
| NCBI Protein Information: | galanin-like peptide; alarin; gal-like peptide |
| UniProt Protein Name: | Galanin-like peptide |
| Protein Family: | Galanin-like peptide |
| UniProt Gene Name: | GALP |
| UniProt Entry Name: | GALP_HUMAN |
 | Western blot analysis of extracts of U-87MG cells, using GALP antibody (CAB17445) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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