Anti-FSTL3 Antibody (CAB10279)
- SKU:
- CAB10279
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-FSTL3 Antibody |
| Antibody SKU: | CAB10279 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-263 of human FSTL3 (NP_005851.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, DU145, MCF7, SKOV3, Mouse lung, Mouse kidney, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-263 of human FSTL3 (NP_005851.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGSG NPAP GGVC WLQQ GQEA TCSL VLQT DVTR AECC ASGN IDTA WSNL THPG NKIN LLGF LGLV HCLP CKDS CDGV ECGP GKAC RMLG GRPR CECA PDCS GLPA RLQV CGSD GATY RDEC ELRA ARCR GHPD LSVM YRGR CRKS CEHV VCPR PQSC VVDQ TGSA HCVV CRAA PCPV PSSP GQEL CGNN NVTY ISSC HMRQ ATCF LGRS IGVR HAGS CAGT PEEP PGGE SAEE EENF V |
| Gene ID: | 10272 |
| Uniprot: | O95633 |
| Cellular Location: | Nucleus, Secreted |
| Calculated MW: | 24kDa/27kDa |
| Observed MW: | 27kDa |
| Synonyms: | FSTL3, FLRG, FSRP |
| Background: | Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. |
| UniProt Protein Function: | FSTL3: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1. 2 isoforms of the human protein are produced by alternative initiation. |
| UniProt Protein Details: | Protein type:Oncoprotein; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: extracellular region; extracellular space; nucleoplasm; nucleus Molecular Function:activin binding; fibronectin binding; protein binding Biological Process: hemopoietic progenitor cell differentiation; negative regulation of activin receptor signaling pathway; negative regulation of BMP signaling pathway; negative regulation of osteoclast differentiation; positive regulation of cell-cell adhesion; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95633 |
| NCBI GenInfo Identifier: | 23821565 |
| NCBI Gene ID: | 10272 |
| NCBI Accession: | O95633.1 |
| UniProt Secondary Accession: | O95633,A8K7E3, |
| UniProt Related Accession: | O95633 |
| Molecular Weight: | 28kDa |
| NCBI Full Name: | Follistatin-related protein 3 |
| NCBI Synonym Full Names: | follistatin like 3 |
| NCBI Official Symbol: | FSTL3 |
| NCBI Official Synonym Symbols: | FLRG; FSRP |
| NCBI Protein Information: | follistatin-related protein 3 |
| UniProt Protein Name: | Follistatin-related protein 3 |
| UniProt Synonym Protein Names: | Follistatin-like protein 3; Follistatin-related gene protein |
| Protein Family: | Follistatin-related protein |
| UniProt Gene Name: | FSTL3 |
 | Western blot analysis of extracts of various cell lines, using FSTL3 antibody (CAB10279) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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