Anti-FN3KRP Antibody (CAB15512)
- SKU:
- CAB15512
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-FN3KRP Antibody |
| Antibody SKU: | CAB15512 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-309 of human FN3KRP (NP_078895.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, U-251MG, MCF7, Mouse brain, Mouse kidney, Mouse lung, Mouse pancreas, Rat spleen, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-309 of human FN3KRP (NP_078895.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEEL LRRE LGCS SVRA TGHS GGGC ISQG RSYD TDQG RVFV KVNP KAEA RRMF EGEM ASLT AILK TNTV KVPK PIKV LDAP GGGS VLVM EHMD MRHL SSHA AKLG AQLA DLHL DNKK LGEM RLKE AGTV GRGG GQEE RPFV ARFG FDVV TCCG YLPQ VNDW QEDW VVFY ARQR IQPQ MDMV EKES GDRE ALQL WSAL QLKI PDLF RDLE IIPA LLHG DLWG GNVA EDSS GPVI FDPA SFYG HSEY ELAI AGMF GGFS SSFY SAYH GKIP KAPG FEKR LQLY QLFH YLNH WNHF GSGY RGSS LNIM RNLV K |
| Gene ID: | 79672 |
| Uniprot: | Q9HA64 |
| Cellular Location: | |
| Calculated MW: | 34kDa |
| Observed MW: | 35kDa |
| Synonyms: | FN3KRP, FN3KL |
| Background: | A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | FN3KRP: Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein- bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation. Belongs to the fructosamine kinase family. |
| UniProt Protein Details: | Protein type:EC 2.7.1.-; Kinase, other Chromosomal Location of Human Ortholog: 17q25.3 Molecular Function:kinase activity Biological Process: phosphorylation |
| NCBI Summary: | A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012] |
| UniProt Code: | Q9HA64 |
| NCBI GenInfo Identifier: | 47606765 |
| NCBI Gene ID: | 79672 |
| NCBI Accession: | Q9HA64.2 |
| UniProt Secondary Accession: | Q9HA64,Q969F4, Q9H0U7, |
| UniProt Related Accession: | Q9HA64 |
| Molecular Weight: | 309 |
| NCBI Full Name: | Ketosamine-3-kinase |
| NCBI Synonym Full Names: | fructosamine 3 kinase related protein |
| NCBI Official Symbol: | FN3KRP |
| NCBI Official Synonym Symbols: | FN3KL |
| NCBI Protein Information: | ketosamine-3-kinase; FN3K-RP; FN3K-related protein; fructosamine-3-kinase-related protein |
| UniProt Protein Name: | Ketosamine-3-kinase |
| UniProt Synonym Protein Names: | Fructosamine-3-kinase-related protein; FN3K-RP; FN3K-related protein |
| Protein Family: | Ketosamine-3-kinase |
| UniProt Gene Name: | FN3KRP |
| UniProt Entry Name: | KT3K_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FN3KRP antibody (CAB15512) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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