Anti-FDX1 Antibody (CAB9815)

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SKU:
CAB9815
Product type:
Antibody
Application:
WB
Application:
IHC
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism
Frequently bought together:

Description

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Antibody Name:Anti-FDX1 Antibody
Antibody SKU:CAB9815
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human FDX1 (NP_004100.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, K-562, DU145
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human FDX1 (NP_004100.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAA GGAR LLRA ASAV LGGP AGRW LHHA GSRA GSSG LLRN RGPG GSAE ASRS LSVS ARAR SSSE DKIT VHFI NRDG ETLT TKGK VGDS LLDV VVEN NLDI DGFG ACEG TLAC STCH LIFE DHIY EKLD AITD EEND MLDL AYGL TDRS RLGC QICL TKSM DNMT VRVP ETVA DARQ SIDV GKTS
Gene ID:2230
Uniprot:P10109
Cellular Location:Mitochondrion matrix
Calculated MW:19kDa
Observed MW:14kDa
Synonyms:FDX1, ADX, FDX, LOH11CR1D
Background:This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21.
UniProt Protein Function:adrenodoxin: Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to cytochrome P450 cholesterol side-chain cleavage enzyme. Belongs to the adrenodoxin/putidaredoxin family.
UniProt Protein Details:

Protein type:Mitochondrial

Chromosomal Location of Human Ortholog: 11q22

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function:2 iron, 2 sulfur cluster binding; electron carrier activity; iron ion binding

Biological Process: steroid metabolic process; cholesterol metabolic process; xenobiotic metabolic process; C21-steroid hormone biosynthetic process; hormone biosynthetic process; sterol metabolic process

NCBI Summary:This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21. [provided by RefSeq, Aug 2011]
UniProt Code:P10109
NCBI GenInfo Identifier:4758352
NCBI Gene ID:2230
NCBI Accession:NP_004100.1
UniProt Secondary Accession:P10109,Q53YD6, B0YJ14,
UniProt Related Accession:P10109
Molecular Weight:19,393 Da
NCBI Full Name:adrenodoxin, mitochondrial
NCBI Synonym Full Names:ferredoxin 1
NCBI Official Symbol:FDX1  
NCBI Official Synonym Symbols:ADX; FDX; LOH11CR1D  
NCBI Protein Information:adrenodoxin, mitochondrial; ferredoxin-1; hepatoredoxin; adrenal ferredoxin; mitochondrial adrenodoxin
UniProt Protein Name:Adrenodoxin, mitochondrial
UniProt Synonym Protein Names:Adrenal ferredoxin; Ferredoxin-1; Hepatoredoxin
Protein Family:Adrenodoxin
UniProt Gene Name:FDX1  
UniProt Entry Name:ADX_HUMAN
Anti-FDX1 Polyclonal Antibody (CAB9815)Western blot analysis of extracts of various cell lines, using FDX1 antibody (CAB9815) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.

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