Anti-FCRL3 항체 (CAB10452)

Antibody Name:	Anti-FCRL3 Antibody
Antibody SKU:	CAB10452
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 18-180 of human FCRL3 (NP_443171.2).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:100 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	U-937, NCI-H460, 293T, HeLa, Mouse kidney

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 18-180 of human FCRL3 (NP_443171.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	GVAP KAVL LLNP PWST AFKG EKVA LICS SISH SLAQ GDTY WYHD EKLL KIKH DKIQ ITEP GNYQ CKTR GSSL SDAV HVEF SPDW LILQ ALHP VFEG DNVI LRCQ GKDN KNTH QKVY YKDG KQLP NSYN LEKI TVNS VSRD NSKY HCTA YRKF YILD IEVT SKP
Gene ID:	115352
Uniprot:	Q96P31
Cellular Location:	Cell membrane, Single-pass type I membrane protein
Calculated MW:	21kDa/22kDa/69kDa/77kDa/80kDa/81kDa
Observed MW:	81kDa

Synonyms:

FCRL3, CD307c, FCRH3, IFGP3, IRTA3, SPAP2

Background:

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	FCRL3: Genetic variation in FCRL3 may be a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. 7 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Adaptor/scaffold; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q23.1
NCBI Summary:	This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
UniProt Code:	Q96P31
NCBI GenInfo Identifier:	74761021
NCBI Gene ID:	115352
NCBI Accession:	Q96P31.1
UniProt Secondary Accession:	Q96P31,Q5VXZ8, Q8N6S2, Q96LA4, Q96P27, Q96P28, Q96P29 Q96P30, A0N0M4, A8MTH7, D3DVD2,
UniProt Related Accession:	Q96P31
Molecular Weight:	81kDa
NCBI Full Name:	Fc receptor-like protein 3
NCBI Synonym Full Names:	Fc receptor like 3
NCBI Official Symbol:	FCRL3
NCBI Official Synonym Symbols:	FCRH3; IFGP3; IRTA3; SPAP2; CD307c
NCBI Protein Information:	Fc receptor-like protein 3
UniProt Protein Name:	Fc receptor-like protein 3
UniProt Synonym Protein Names:	Fc receptor homolog 3; FcRH3; IFGP family protein 3; hIFGP3; Immune receptor translocation-associated protein 3; SH2 domain-containing phosphatase anchor protein 2; CD_antigen: CD307c
Protein Family:	Fc receptor-like protein
UniProt Gene Name:	FCRL3

Western blot analysis of extracts of various cell lines, using FCRL3 antibody (CAB10452) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

Antibodies

Anti-FCRL3 Antibody (CAB10451)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)