Anti-DPP10 Antibody (CAB16563)

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SKU:
CAB16563
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-DPP10 Antibody
Antibody SKU:CAB16563
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 400-500 of human DPP10 (NP_001308842.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:U-251MG
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 400-500 of human DPP10 (NP_001308842.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GYIA SMIL KSDE KLFK CGSV VAPI TDLK LYAS AFSE RYLG MPSK EEST YQAA SVLH NVHG LKEE NILI IHGT ADTK VHFQ HSAE LIKH LIKA GVNY TMQV Y
Gene ID:57628
Uniprot:Q8N608
Cellular Location:Cell membrane, Single-pass type II membrane protein
Calculated MW:85kDa/90kDa/91kDa
Observed MW:110kDa
Synonyms:DPP10, DPL2, DPPY, DPRP-3, DPRP3
Background:This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
UniProt Protein Function:Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155).
NCBI Summary:This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:Q8N608
NCBI GenInfo Identifier:296434483
NCBI Gene ID:57628
NCBI Accession:Q8N608.2
UniProt Secondary Accession:Q8N608,Q0GLB8, Q53QT3, Q53S86, Q53SL8, Q53SS4, Q6TTV4 Q86YR9, Q9P236, A8K1Q2, J3KPP2, J3KQ46,
UniProt Related Accession:Q8N608
Molecular Weight:85,480 Da
NCBI Full Name:Inactive dipeptidyl peptidase 10
NCBI Synonym Full Names:dipeptidyl peptidase like 10
NCBI Official Symbol:DPP10  
NCBI Official Synonym Symbols:DPL2; DPPY; DPRP3; DPRP-3  
NCBI Protein Information:inactive dipeptidyl peptidase 10
UniProt Protein Name:Inactive dipeptidyl peptidase 10
UniProt Synonym Protein Names:Dipeptidyl peptidase IV-related protein 3; DPRP-3; Dipeptidyl peptidase X; DPP X; Dipeptidyl peptidase-like protein 2; DPL2
Protein Family:Inactive dipeptidyl peptidase
UniProt Gene Name:DPP10  
UniProt Entry Name:DPP10_HUMAN
Anti-DPP10 Antibody (CAB16563)Western blot analysis of extracts of U-251MG cells, using DPP10 antibody (CAB16563) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.

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