Anti-DNAJC5 Antibody (CAB10489)
- SKU:
- CAB10489
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-DNAJC5 Antibody |
| Antibody SKU: | CAB10489 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human DNAJC5 (NP_079495.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:1000 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse liver, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human DNAJC5 (NP_079495.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MADQ RQRS LSTS GESL YHVL GLDK NATS DDIK KSYR KLAL KYHP DKNP DNPE AADK FKEI NNAH AILT DATK RNIY DKYG SLGL YVAE QFGE ENVN TYFV LSSW WAKA LFVF CGLL TCCY CCCC LCCC FNCC CGKC KPKA PEGE ETEF YVSP EDLE AQLQ SDER EATD TPIV IQPA SATE TTQL TADS HPSY HTDG FN |
| Gene ID: | 80331 |
| Uniprot: | Q9H3Z4 |
| Cellular Location: | Cell membrane, Lipid-anchor, Melanosome, Membrane |
| Calculated MW: | 18kDa/22kDa |
| Observed MW: | 30kDa |
| Synonyms: | DNAJC5, CLN4, CLN4B, CSP, DNAJC5A, NCL, mir-941-2, mir-941-3, mir-941-4, mir-941-5 |
| Background: | This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. |
| UniProt Protein Function: | DNAJC5: a cysteine string protein that inhibits N-type calcium channels which is blocked by huntingtin mutants. May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings. Modulates the maturation of cystic fibrosis transmembrane conductance regulator. Two splice-variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 20q13.33 Cellular Component: lysosomal membrane; membrane; mitochondrion; plasma membrane Biological Process: neurotransmitter secretion; regulated secretory pathway; synaptic vesicle exocytosis |
| NCBI Summary: | This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010] |
| UniProt Code: | Q9H3Z4 |
| NCBI GenInfo Identifier: | 15213953 |
| NCBI Gene ID: | 80331 |
| NCBI Accession: | Q9H3Z4.1 |
| UniProt Secondary Accession: | Q9H3Z4,Q9H3Z5, Q9H7H2, A8K0M0, B3KY68, E1P5G8, |
| UniProt Related Accession: | Q9H3Z4 |
| Molecular Weight: | 18,801 Da |
| NCBI Full Name: | DnaJ homolog subfamily C member 5 |
| NCBI Synonym Full Names: | DnaJ heat shock protein family (Hsp40) member C5 |
| NCBI Official Symbol: | DNAJC5 |
| NCBI Official Synonym Symbols: | CSP; NCL; CLN4; CLN4B; DNAJC5A; mir-941-2; mir-941-3; mir-941-4; mir-941-5 |
| NCBI Protein Information: | dnaJ homolog subfamily C member 5 |
| UniProt Protein Name: | DnaJ homolog subfamily C member 5 |
| UniProt Synonym Protein Names: | Ceroid-lipofuscinosis neuronal protein 4 |
| Protein Family: | DnaJ homolog subfamily |
| UniProt Gene Name: | DNAJC5 |
| UniProt Entry Name: | DNJC5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DNAJC5 antibody (CAB10489) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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