Anti-CTSV Antibody (CAB7662)
- SKU:
- CAB7662
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CTSV Antibody |
| Antibody SKU: | CAB7662 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 105-334 of human CTSV (NP_001324.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, A-549, Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 105-334 of human CTSV (NP_001324.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VFRE PLFL DLPK SVDW RKKG YVTP VKNQ KQCG SCWA FSAT GALE GQMF RKTG KLVS LSEQ NLVD CSRP QGNQ GCNG GFMA RAFQ YVKE NGGL DSEE SYPY VAVD EICK YRPE NSVA NDTG FTVV APGK EKAL MKAV ATVG PISV AMDA GHSS FQFY KSGI YFEP DCSS KNLD HGVL VVGY GFEG ANSN NSKY WLVK NSWG PEWG SNGY VKIA KDKN NHCG IATA ASYP NV |
| Gene ID: | 1515 |
| Uniprot: | O60911 |
| Cellular Location: | Lysosome |
| Calculated MW: | 37kDa |
| Observed MW: | 37kDa |
| Synonyms: | CTSV, CATL2, CTSL2, CTSU |
| Background: | The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. |
| UniProt Protein Function: | CTSL2: Cysteine protease. May have an important role in corneal physiology. Belongs to the peptidase C1 family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; EC 3.4.22.15; Protease Chromosomal Location of Human Ortholog: 9q22.2 Cellular Component: extracellular space; lysosomal lumen; neuron projection; microvillus; apical part of cell; extracellular region; nucleolus; perikaryon; external side of plasma membrane; secretory granule Molecular Function:protein binding; histone binding; cysteine-type endopeptidase activity; protein complex binding; aminopeptidase activity; cysteine-type carboxypeptidase activity; kininogen binding; peptide binding; cysteine-type peptidase activity Biological Process: extracellular matrix organization and biogenesis; hair follicle morphogenesis; response to glucocorticoid stimulus; Sertoli cell differentiation; antigen processing and presentation of exogenous peptide antigen via MHC class II; multicellular organismal aging; decidualization; proteolysis; cellular response to starvation; extracellular matrix disassembly; protein autoprocessing; response to glucose stimulus; autophagic cell death; spermatogenesis; nerve development |
| NCBI Summary: | The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011] |
| UniProt Code: | O60911 |
| NCBI GenInfo Identifier: | 12644075 |
| NCBI Gene ID: | 1515 |
| NCBI Accession: | O60911.2 |
| UniProt Secondary Accession: | O60911,O60233, Q2TB86, Q5T1U0, |
| UniProt Related Accession: | O60911 |
| Molecular Weight: | 334 |
| NCBI Full Name: | Cathepsin L2 |
| NCBI Synonym Full Names: | cathepsin V |
| NCBI Official Symbol: | CTSV |
| NCBI Official Synonym Symbols: | CTSU; CATL2; CTSL2 |
| NCBI Protein Information: | cathepsin L2; cathepsin U; cathepsin L2, preproprotein |
| UniProt Protein Name: | Cathepsin L2 |
| UniProt Synonym Protein Names: | Cathepsin U; Cathepsin V |
| UniProt Gene Name: | CTSV |
| UniProt Entry Name: | CATL2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CTSV antibody (CAB7662) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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