Anti-CRTAP Antibody (CAB4428)

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SKU:
CAB4428
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CRTAP
Synonyms:
CASP
Synonyms:
LEPREL3
Synonyms:
OI7
Synonyms:
P3H5
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Description

Product Name:CRTAP Rabbit pAb
Product Code:CAB4428
Size:20uL, 50uL, 100uL
Synonyms:CRTAP, CASP, LEPREL3, OI7, P3H5
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-240 of human CRTAP (NP_006362.1).
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:SW480
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-240 of human CRTAP (NP_006362.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ALRA GRAQ YERY SFRS FPRD ELMP LESA YRHA LDKY SGEH WAES VGYL EISL RLHR LLRD SEAF CHRN CSAA PQPE PAAG LASY PELR LFGG LLRR AHCL KRCK QGLP AFRQ SQPS REVL ADFQ RREP YKFL QFAY FKAN NLPK AIAA AHTF LLKH PDDE MMKR NMAY YKSL PGAE DYIK DLET KSYE SLFI RAVR AYNG ENWR TSIT DMEL ALPD FFKA F
Gene ID:10491
Uniprot:O75718
Cellular Location:Secreted, extracellular matrix, extracellular space
Calculated MW:46kDa
Observed MW:47kDa
UniProt Protein Function:CRTAP: Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues. Defects in CRTAP are the cause of osteogenesis imperfecta type 7 (OI7). A connective tissue disorder characterized by short stature, short humeri and femora, coxa vara, white sclera, and the absence of dentinogenesis imperfecta. Multiple fractures are present at birth, and patients manifest moderate-severe bone fragility. Death may occurr in the perinatal period due to secondary respiratory insufficiency. Belongs to the leprecan family.
UniProt Protein Details:

Protein type:Extracellular matrix; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3p22.3

Cellular Component: proteinaceous extracellular matrix; extracellular space; endoplasmic reticulum lumen; endoplasmic reticulum

Molecular Function:protein complex binding

Biological Process: extracellular matrix organization and biogenesis; protein stabilization; spermatogenesis; peptidyl-proline hydroxylation to 3-hydroxy-L-proline

Disease: Osteogenesis Imperfecta, Type Vii

NCBI Summary:The protein encoded by this gene is similar to the chicken and mouse CRTAP genes. The encoded protein is a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli. Defects in this gene are associated with osteogenesis imperfecta, a connective tissue disorder characterized by bone fragility and low bone mass. [provided by RefSeq, Jul 2008]
UniProt Code:O75718
NCBI GenInfo Identifier:17372894
NCBI Gene ID:10491
NCBI Accession:O75718.1
UniProt Related Accession:O75718
Molecular Weight:46562
NCBI Full Name:Cartilage-associated protein
NCBI Synonym Full Names:cartilage associated protein
NCBI Official Symbol:CRTAP  
NCBI Official Synonym Symbols:OI7; CASP; P3H5; LEPREL3  
NCBI Protein Information:cartilage-associated protein
UniProt Protein Name:Cartilage-associated protein
Protein Family:Cartilage-associated protein
UniProt Gene Name:CRTAP  
UniProt Entry Name:CRTAP_HUMAN
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