| Background: | This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | CRLF2: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. Belongs to the type I cytokine receptor family. Type 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: Xp22.33 and Yp11.2 |
| NCBI Summary: | This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014] |
| UniProt Code: | Q9HC73 |
| NCBI GenInfo Identifier: | 38257768 |
| NCBI Gene ID: | 64109 |
| NCBI Accession: | Q9HC73.1 |
| UniProt Secondary Accession: | Q9HC73,Q5G7M1, Q9H5R3, J3QKD1, |
| UniProt Related Accession: | Q9HC73 |
| Molecular Weight: | 29,360 Da |
| NCBI Full Name: | Cytokine receptor-like factor 2 |
| NCBI Synonym Full Names: | cytokine receptor-like factor 2 |
| NCBI Official Symbol: | CRLF2 |
| NCBI Official Synonym Symbols: | CRL2; TSLPR; CRLF2Y |
| NCBI Protein Information: | cytokine receptor-like factor 2 |
| UniProt Protein Name: | Cytokine receptor-like factor 2 |
| UniProt Synonym Protein Names: | Cytokine receptor-like 2; IL-XR; Thymic stromal lymphopoietin protein receptor; TSLP receptor |
| Protein Family: | Thymic stromal lymphopoietin |
| UniProt Gene Name: | CRLF2 |
