Anti-COX8A Antibody (CAB3290)
- SKU:
- CAB3290
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-COX8A Antibody |
| Antibody SKU: | CAB3290 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-69 of human COX8A (NP_004065.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-69 of human COX8A (NP_004065.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSVL TPLL LRGL TGSA RRLP VPRA KIHS LPPE GKLG IMEL AVGL TSCF VTFL LPAG WILS HLET YRRP E |
| Gene ID: | 1351 |
| Uniprot: | P10176 |
| Cellular Location: | Mitochondrion inner membrane |
| Calculated MW: | 7kDa |
| Observed MW: | 8kDa |
| Synonyms: | COX8A, COX, COX8, COX8-2, COX8L, VIII, VIII-L |
| Background: | The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. |
| UniProt Protein Function: | COX8A: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Belongs to the cytochrome c oxidase VIII family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Energy Metabolism - oxidative phosphorylation; Mitochondrial Chromosomal Location of Human Ortholog: 11q12-q13 Cellular Component: mitochondrial inner membrane; integral to membrane Molecular Function:cytochrome-c oxidase activity Biological Process: cellular metabolic process; generation of precursor metabolites and energy; transmembrane transport |
| NCBI Summary: | The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P10176 |
| NCBI GenInfo Identifier: | 117132 |
| NCBI Gene ID: | 1351 |
| NCBI Accession: | P10176.2 |
| UniProt Secondary Accession: | P10176,P15955, |
| UniProt Related Accession: | P10176 |
| Molecular Weight: | 7,579 Da |
| NCBI Full Name: | Cytochrome c oxidase subunit 8A, mitochondrial |
| NCBI Synonym Full Names: | cytochrome c oxidase subunit VIIIA (ubiquitous) |
| NCBI Official Symbol: | COX8A |
| NCBI Official Synonym Symbols: | COX; COX8; VIII; COX8L; COX8-2; VIII-L |
| NCBI Protein Information: | cytochrome c oxidase subunit 8A, mitochondrial; cytochrome c oxidase polypeptide VIII-liver/heart; cytochrome c oxidase subunit 8-2; cytochrome c oxidase subunit 8A (ubiquitous); cytochrome c oxidase subunit VIII |
| UniProt Protein Name: | Cytochrome c oxidase subunit 8A, mitochondrial |
| UniProt Synonym Protein Names: | Cytochrome c oxidase polypeptide VIII-liver/heart; Cytochrome c oxidase subunit 8-2 |
| UniProt Gene Name: | COX8A |
| UniProt Entry Name: | COX8A_HUMAN |
 | Western blot analysis of extracts of mouse skeletal muscle, using COX8A antibody (CAB3290). |
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