Anti-CLC Antibody (CAB15265)
- SKU:
- CAB15265
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CLC Antibody |
| Antibody SKU: | CAB15265 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human CLC (NP_001819.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HepG2, HL-60 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human CLC (NP_001819.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSLL PVPY TEAA SLST GSTV TIKG RPLA CFLN EPYL QVDF HTEM KEES DIVF HFQV CFGR RVVM NSRE YGAW KQQV ESKN MPFQ DGQE FELS ISVL PDKY QVMV NGQS SYTF DHRI KPEA VKMV QVWR DISL TKFN VSYL KR |
| Gene ID: | 1178 |
| Uniprot: | Q05315 |
| Cellular Location: | Cytoplasm, Cytoplasmic granule, cytosol |
| Calculated MW: | 16kDa |
| Observed MW: | 14kDa |
| Synonyms: | CLC, GAL10, Gal-10, LGALS10, LGALS10A, LPPL_HUMAN |
| Background: | Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. |
| UniProt Protein Function: | Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). |
| NCBI Summary: | Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q05315 |
| NCBI GenInfo Identifier: | 317373429 |
| NCBI Gene ID: | 1178 |
| NCBI Accession: | Q05315.3 |
| UniProt Secondary Accession: | Q05315,Q0VDE3, C5HZ13, C5HZ14, |
| UniProt Related Accession: | Q05315 |
| Molecular Weight: | 16,453 Da |
| NCBI Full Name: | Galectin-10 |
| NCBI Synonym Full Names: | Charcot-Leyden crystal galectin |
| NCBI Official Symbol: | CLC |
| NCBI Official Synonym Symbols: | GAL10; Gal-10; LGALS10; LGALS10A; LPPL_HUMAN |
| NCBI Protein Information: | galectin-10 |
| UniProt Protein Name: | Galectin-10 |
| UniProt Synonym Protein Names: | Charcot-Leyden crystal protein; CLC; Eosinophil lysophospholipase; Lysolecithin acylhydrolase |
| Protein Family: | Clathrin |
| UniProt Gene Name: | CLC |
| UniProt Entry Name: | LEG10_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLC antibody (CAB15265) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90S. |
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