Anti-CIZ1 Antibody (CAB17349)

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SKU:
CAB17349
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-CIZ1 Antibody
Antibody SKU:CAB17349
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 250-440 of human CIZ1 (NP_001124490).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:mouse testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 250-440 of human CIZ1 (NP_001124490).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PGQL QVKA QPQA RMTV PKQT QTPD LLPE ALEA QVLP RFQP RVLQ VQAQ VQSQ TQPR IPST DTQV QPKL QKQA QTQT SPEH LVLQ QKQV QPQL QQEA EPQK QVQP QVHT QAQP SVQP QEHP PAQV SVQP PEQT HEQP HTQP QVSL LAPE QTPV VVHV CGLE MPPD AVEA GGGM EKTL PEPV GTQV SMEE IQN
Gene ID:25792
Uniprot:Q9ULV3
Cellular Location:
Calculated MW:100kDa
Observed MW:100kDa
Synonyms:CIZ1, LSFR1, NP94, ZNF356
Background:The protein encoded by this gene is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:CIZ1: May regulate the subcellular localization of CIP/WAF1. Defects in CIZ1 may be a cause of adult onset primary cervical dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Cervical dystonia or spasmodic torticollis, the most common form of focal dystonia, is characterized by involuntary contractions of the neck muscles, which produce abnormal posturing of the head upon the trunk. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell cycle regulation

Chromosomal Location of Human Ortholog: 9q34.1

Cellular Component: nucleus

Molecular Function:protein binding; nucleic acid binding; zinc ion binding

NCBI Summary:The protein encoded by this gene is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
UniProt Code:Q9ULV3
NCBI GenInfo Identifier:42544179
NCBI Gene ID:25792
NCBI Accession:NP_036259.2
UniProt Secondary Accession:Q9ULV3,Q5SYW3, Q5SYW5, Q8WU72, Q9H868, Q9NYM8, Q9UHK4 Q9Y3F9, Q9Y3G0, A8K9J8, B4E131, B7ZAS8,
UniProt Related Accession:Q9ULV3
Molecular Weight:88,520 Da
NCBI Full Name:cip1-interacting zinc finger protein isoform 1
NCBI Synonym Full Names:CDKN1A interacting zinc finger protein 1
NCBI Official Symbol:CIZ1  
NCBI Official Synonym Symbols:NP94; LSFR1; ZNF356  
NCBI Protein Information:cip1-interacting zinc finger protein; nuclear protein NP94; zinc finger protein 356
UniProt Protein Name:Cip1-interacting zinc finger protein
UniProt Synonym Protein Names:CDKN1A-interacting zinc finger protein 1; Nuclear protein NP94; Zinc finger protein 356
Protein Family:Cip1-interacting zinc finger protein
UniProt Gene Name:CIZ1  
UniProt Entry Name:CIZ1_HUMAN
Anti-CIZ1 Antibody (CAB17349)Western blot analysis of extracts of mouse testis, using CIZ1 antibody (CAB17349) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

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