Anti-CHRFAM7A Antibody (CAB7844)
- SKU:
- CAB7844
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CHRFAM7A Antibody |
| Antibody SKU: | CAB7844 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human CHRFAM7A (NP_647536.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, Jurkat, SH-SY5Y, U-87MG, NIH/3T3, Mouse brain, Mouse spinal cord, Rat brain, Rat spinal cord |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human CHRFAM7A (NP_647536.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MQKY CIYQ HFQF QLLI QHLW IAAN CDIA DERF DATF HTNV LVNS SGHC QYLP PGIF KSSC YIDV RWFP FDVQ HCKL KFGS WSYG GWSL DLQM QEAD ISGY IPNG EWDL VGIP GKRS ERFY ECCK EPYP DVTF TVTM RRRT LYYG LNLL IP |
| Gene ID: | 89832 |
| Uniprot: | Q494W8 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 46kDa |
| Observed MW: | 46kDa |
| Synonyms: | CHRFAM7A, CHRNA7, CHRNA7-DR1, D-10 |
| Background: | The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. |
| UniProt Protein Function: | CHRFAM7A: Belongs to the ligand-gated ion channel (TC 1.A.9) family |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 15q13.1 Cellular Component: integral to membrane Molecular Function:extracellular ligand-gated ion channel activity |
| NCBI Summary: | The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q494W8 |
| NCBI GenInfo Identifier: | 91208254 |
| NCBI Gene ID: | 89832 |
| NCBI Accession: | Q494W8.1 |
| UniProt Related Accession: | Q494W8 |
| Molecular Weight: | 46kDa |
| NCBI Full Name: | CHRNA7-FAM7A fusion protein |
| NCBI Synonym Full Names: | CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion |
| NCBI Official Symbol: | CHRFAM7A |
| NCBI Official Synonym Symbols: | D-10; CHRNA7; NACHRA7; CHRNA7-DR1 |
| NCBI Protein Information: | CHRNA7-FAM7A fusion protein |
| UniProt Protein Name: | CHRNA7-FAM7A fusion protein |
| UniProt Synonym Protein Names: | CHRNA7-DR1; D-10 |
| Protein Family: | CHRNA7-FAM7A fusion protein |
| UniProt Gene Name: | CHRFAM7A |
| UniProt Entry Name: | CRFM7_HUMAN |
 | Immunohistochemistry of paraffin-embedded human prostate using CHRFAM7A antibody (CAB7844) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using CHRFAM7A antibody (CAB7844) at dilution of 1:100 (40x lens). |
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