| UniProt Protein Function: | CDK5R1: activator of cyclin-dependent kinase 5 (CDK5). Required for proper development of the central nervous system. The p35 form of this protein is cleaved by calpain, generating a p25 form, resulting in the prolonged activation and relocalization of the CDK5 from the cell periphery to nuclear and perinuclear regions. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease, leading to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. |
| UniProt Protein Details: | Protein type:Protein kinase, regulatory subunit Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: cyclin-dependent protein kinase 5 activator complex; contractile fiber; intracellular membrane-bound organelle; dendrite; postsynaptic density; dendritic spine; cytosol; nucleoplasm; growth cone; membrane; cell soma; perinuclear region of cytoplasm; axon; cytoplasm; plasma membrane; nucleus; neuromuscular junction Molecular Function:protein serine/threonine kinase activator activity; protein binding; ephrin receptor binding; cadherin binding; cyclin-dependent protein kinase activity; cyclin-dependent protein kinase 5 activator activity; kinase activity; calcium ion binding; protein kinase binding; protein kinase activity Biological Process: superior olivary nucleus maturation; axon guidance; acetylcholine receptor signaling, muscarinic pathway; regulation of neuron differentiation; hippocampus development; axonal fasciculation; peptidyl-threonine phosphorylation; rhythmic process; neuron migration; negative regulation of axon extension; neuron differentiation; cell proliferation; embryonic development; peptidyl-serine phosphorylation; ionotropic glutamate receptor signaling pathway; positive regulation of neuron apoptosis; regulation of actin cytoskeleton organization and biogenesis; ephrin receptor signaling pathway; cerebellum development; neuron adhesion; brain development; regulation of cyclin-dependent protein kinase activity; negative regulation of transcription, DNA-dependent; neurite development; layer formation in the cerebral cortex; serine phosphorylation of STAT3 protein |
| NCBI Summary: | The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15078 |
| NCBI GenInfo Identifier: | 2498217 |
| NCBI Gene ID: | 8851 |
| NCBI Accession: | Q15078.1 |
| UniProt Secondary Accession: | Q15078,Q5U0G3, E1P664, |
| UniProt Related Accession: | Q15078 |
| Molecular Weight: | 307 |
| NCBI Full Name: | Cyclin-dependent kinase 5 activator 1 |
| NCBI Synonym Full Names: | cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
| NCBI Official Symbol: | CDK5R1 |
| NCBI Official Synonym Symbols: | p23; p25; p35; CDK5R; NCK5A; CDK5P35; p35nck5a |
| NCBI Protein Information: | cyclin-dependent kinase 5 activator 1; CDK5 activator 1; neuronal CDK5 activator; TPKII regulatory subunit; regulatory partner for CDK5 kinase; tau protein kinase II 23kDa subunit; cyclin-dependent kinase 5 regulatory subunit 1 |
| UniProt Protein Name: | Cyclin-dependent kinase 5 activator 1 |
| UniProt Synonym Protein Names: | Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunitCleaved into the following 2 chains:Cyclin-dependent kinase 5 activator 1, p35; p35; Cyclin-dependent kinase 5 activator 1, p25; p25Alternative name(s):Tau protein kinase II 23 kDa subunit; p23 |
| Protein Family: | Cyclin-dependent kinase 5 activator |
| UniProt Gene Name: | CDK5R1 |
| UniProt Entry Name: | CD5R1_HUMAN |
