Anti-CD300A Antibody (CAB10006)

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SKU:
CAB10006
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-CD300A Antibody
Antibody SKU:CAB10006
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 18-180 of human CD300A (NP_009192.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:1000
Reactivity:Human
Positive Samples:K-562
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 18-180 of human CD300A (NP_009192.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LSKC RTVA GPVG GSLS VQCP YEKE HRTL NKYW CRPP QIFL CDKI VETK GSAG KRNG RVSI RDSP ANLS FTVT LENL TEED AGTY WCGV DTPW LRDF HDPV VEVE VSVF PAST SMTP ASIT AAKT STIT TAFP PVSS TTLF AVGA THSA SIQE ETEE VVNS QLP
Gene ID:11314
Uniprot:Q9UGN4
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:11kDa/16kDa/20kDa/33kDa
Observed MW:67kDa
Synonyms:CD300A, CLM-8, CMRF-35-H9, CMRF-35H, CMRF35-H, CMRF35-H9, CMRF35H, CMRF35H9, IGSF12, IRC1, IRC1/IRC2, IRC2, IRp60
Background:This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:MAIR-I: Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Belongs to the CD300 family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: membrane; plasma membrane

Molecular Function:phosphatidylethanolamine binding; phosphatidylserine binding; protein binding

Biological Process: negative regulation of B cell proliferation; negative regulation of B cell receptor signaling pathway; negative regulation of fibroblast proliferation; negative regulation of MAP kinase activity; negative regulation of mast cell activation during immune response; negative regulation of mast cell degranulation; negative regulation of MyD88-dependent toll-like receptor signaling pathway; negative regulation of NK T cell activation; negative regulation of phagocytosis, engulfment; neutrophil degranulation; positive regulation of phosphoprotein phosphatase activity; regulation of immune response; regulation of T cell receptor signaling pathway

NCBI Summary:This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Code:Q9UGN4
NCBI GenInfo Identifier:126302534
NCBI Gene ID:11314
NCBI Accession:Q9UGN4.2
UniProt Secondary Accession:Q9UGN4,O95100, Q9HD97, Q9P0F3, Q9UBK4, Q9UMS9, Q9UMT0 A8MW96,
UniProt Related Accession:Q9UGN4
Molecular Weight:33kDa
NCBI Full Name:CMRF35-like molecule 8
NCBI Synonym Full Names:CD300a molecule
NCBI Official Symbol:CD300A  
NCBI Official Synonym Symbols:IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9  
NCBI Protein Information:CMRF35-like molecule 8
UniProt Protein Name:CMRF35-like molecule 8
UniProt Synonym Protein Names:CD300 antigen-like family member A; CMRF-35-H9; CMRF35-H9; CMRF35-H; IRC1/IRC2; Immunoglobulin superfamily member 12; IgSF12; Inhibitory receptor protein 60; IRp60; NK inhibitory receptor; CD_antigen: CD300a
Protein Family:CMRF35-like molecule
UniProt Gene Name:CD300A  
Anti-CD300A Antibody (CAB10006)Western blot analysis of extracts of K-562 cells, using CD300A antibody (CAB10006) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.

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