Anti-CCT7 Antibody (CAB12146)
- SKU:
- CAB12146
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CCT7 Antibody |
| Antibody SKU: | CAB12146 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 310-500 of human CCT7 (NP_006420.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, A-431, HT-29, HeLa, NIH/3T3, Mouse testis, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 310-500 of human CCT7 (NP_006420.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | CAGR VPEE DLKR TMMA CGGS IQTS VNAL SADV LGRC QVFE ETQI GGER YNFF TGCP KAKT CTFI LRGG AEQF MEET ERSL HDAI MIVR RAIK NDSV VAGG GAIE MELS KYLR DYSR TIPG KQQL LIGA YAKA LEII PRQL CDNA GFDA TNIL NKLR ARHA QGGT WYGV DINN EDIA DNFE AFVW EPAM VRI |
| Gene ID: | 10574 |
| Uniprot: | Q99832 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 37kDa/50kDa/54kDa/59kDa |
| Observed MW: | 55kDa |
| Synonyms: | CCT7, CCTETA, CCTH, NIP7-1, TCP1ETA |
| Background: | This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. |
| UniProt Protein Function: | CCT7: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. Belongs to the TCP-1 chaperonin family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Chaperone Chromosomal Location of Human Ortholog: 2p13.2 Cellular Component: chaperonin-containing T-complex; cytoplasm; cytosol; microtubule Molecular Function:protein binding; unfolded protein binding Biological Process: 'de novo' protein folding; positive regulation of telomere maintenance via telomerase; protein folding; protein stabilization |
| NCBI Summary: | This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q99832 |
| NCBI GenInfo Identifier: | 3041738 |
| NCBI Gene ID: | 10574 |
| NCBI Accession: | Q99832.2 |
| UniProt Secondary Accession: | Q99832,O14871, Q6FI26, A8K7E6, A8MWI8, B7WNW9, B7Z4T9 B7Z4Z7, |
| UniProt Related Accession: | Q99832 |
| Molecular Weight: | 59kDa |
| NCBI Full Name: | T-complex protein 1 subunit eta |
| NCBI Synonym Full Names: | chaperonin containing TCP1 subunit 7 |
| NCBI Official Symbol: | CCT7 |
| NCBI Official Synonym Symbols: | CCTH; CCTETA; NIP7-1; TCP1ETA |
| NCBI Protein Information: | T-complex protein 1 subunit eta |
| UniProt Protein Name: | T-complex protein 1 subunit eta |
| UniProt Synonym Protein Names: | CCT-eta; HIV-1 Nef-interacting protein |
| Protein Family: | Probable T-complex protein |
| UniProt Gene Name: | CCT7 |
 | Western blot analysis of extracts of various cell lines, using CCT7 antibody (CAB12146) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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