| UniProt Protein Function: | CCR7: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral Chromosomal Location of Human Ortholog: 17q12-q21.2 Cellular Component: cell surface; plasma membrane; integral to membrane; intracellular; external side of plasma membrane Molecular Function:G-protein coupled receptor activity; C-C chemokine receptor activity Biological Process: positive regulation of cell adhesion; positive regulation of interleukin-12 production; positive regulation of dendritic cell antigen processing and presentation; positive regulation of JNK cascade; response to lipopolysaccharide; elevation of cytosolic calcium ion concentration; positive regulation of T cell receptor signaling pathway; positive regulation of humoral immune response; dendritic cell chemotaxis; establishment of T cell polarity; positive regulation of cell-matrix adhesion; inflammatory response; positive regulation of filopodium formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of hypersensitivity; positive regulation of phosphoinositide 3-kinase activity; negative thymic T cell selection; positive regulation of protein kinase B signaling cascade; G-protein coupled receptor protein signaling pathway; myeloid dendritic cell chemotaxis; positive regulation of pseudopodium formation; positive regulation of actin filament polymerization; regulation of interferon-gamma production; release of sequestered calcium ion into cytosol; positive regulation of protein kinase activity; ruffle organization and biogenesis; regulation of interleukin-1 beta secretion; immune response |
| NCBI Summary: | The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P32248 |
| NCBI GenInfo Identifier: | 1352335 |
| NCBI Gene ID: | 1236 |
| NCBI Accession: | P32248.2 |
| UniProt Related Accession: | P32248 |
| Molecular Weight: | 378 |
| NCBI Full Name: | C-C chemokine receptor type 7 |
| NCBI Synonym Full Names: | chemokine (C-C motif) receptor 7 |
| NCBI Official Symbol: | CCR7 |
| NCBI Official Synonym Symbols: | BLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7 |
| NCBI Protein Information: | C-C chemokine receptor type 7; MIP-3 beta receptor; CC chemokine receptor 7; Bukitt's lymphoma receptor 2; Epstein-Barr virus induced gene 1; EBV-induced G protein-coupled receptor 1; lymphocyte-specific G protein-coupled peptide receptor; Epstein-Barr virus-induced G-protein coupled receptor 1 |
| UniProt Protein Name: | C-C chemokine receptor type 7 |
| UniProt Synonym Protein Names: | BLR2; CDw197; Epstein-Barr virus-induced G-protein coupled receptor 1; EBI1; EBV-induced G-protein coupled receptor 1; MIP-3 beta receptor; CD_antigen: CD197 |
| Protein Family: | C-C chemokine receptor |
| UniProt Gene Name: | CCR7 |
| UniProt Entry Name: | CCR7_HUMAN |
