Anti-CCL28 Antibody (CAB2596)
- SKU:
- CAB2596
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CCL28 Antibody |
| Antibody SKU: | CAB2596 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-127 of human CCL28 (NP_683513.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HT-29, Jurkat, BT-474 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-127 of human CCL28 (NP_683513.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SEAI LPIA SSCC TEVS HHIS RRLL ERVN MCRI QRAD GDCD LAAV ILHV KRRR ICVS PHNH TVKQ WMKV QAAK KNGK GNVC HRKK HHGK RNSN RAHQ GKHE TYGH KTPY |
| Gene ID: | 56477 |
| Uniprot: | Q9NRJ3 |
| Cellular Location: | Secreted |
| Calculated MW: | 12kDa/14kDa |
| Observed MW: | 14kDa |
| Synonyms: | CCL28, CCK1, MEC, SCYA28 |
| Background: | This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. |
| UniProt Protein Function: | CCL28: Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner. Belongs to the intercrine beta (chemokine CC) family. |
| UniProt Protein Details: | Protein type:Chemokine; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 5p12 Cellular Component: extracellular space; extracellular region Molecular Function:chemokine activity Biological Process: elevation of cytosolic calcium ion concentration; immune response; chemotaxis; positive regulation of cell-matrix adhesion; response to nutrient |
| NCBI Summary: | This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014] |
| UniProt Code: | Q9NRJ3 |
| NCBI GenInfo Identifier: | 12230650 |
| NCBI Gene ID: | 56477 |
| NCBI Accession: | Q9NRJ3.1 |
| UniProt Secondary Accession: | Q9NRJ3,D7RIE7, |
| UniProt Related Accession: | Q9NRJ3 |
| Molecular Weight: | 12,375 Da |
| NCBI Full Name: | C-C motif chemokine 28 |
| NCBI Synonym Full Names: | chemokine (C-C motif) ligand 28 |
| NCBI Official Symbol: | CCL28 |
| NCBI Official Synonym Symbols: | MEC; CCK1; SCYA28 |
| NCBI Protein Information: | C-C motif chemokine 28; CC chemokine CCL28; small inducible cytokine A28; small-inducible cytokine A28; mucosae-associated epithelial chemokine; chemokine (C-C motif) ligand 28 splice variant chi; small inducible cytokine subfamily A (Cys-Cys), member 28 |
| UniProt Protein Name: | C-C motif chemokine 28 |
| UniProt Synonym Protein Names: | Mucosae-associated epithelial chemokine; MEC; Protein CCK1; Small-inducible cytokine A28 |
| Protein Family: | Meckelin |
| UniProt Gene Name: | CCL28 |
| UniProt Entry Name: | CCL28_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CCL28 antibody (CAB2596) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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