Anti-CCKBR Antibody (CAB2941)
- SKU:
- CAB2941
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CCKBR Antibody |
| Antibody SKU: | CAB2941 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human CCKBR |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Human stomach cancer tissue |
| Immunogen: | A synthetic peptide of human CCKBR |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 887 |
| Uniprot: | P32239 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 41kDa/48kDa/55kDa |
| Observed MW: | 50kDa |
| Synonyms: | CCKBR, CCK-B, CCK2R, GASR |
| Background: | This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. |
| UniProt Protein Function: | CCKBR: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral Chromosomal Location of Human Ortholog: 11p15.4 Cellular Component: cytosol; integral to plasma membrane; plasma membrane Molecular Function:1-phosphatidylinositol-3-kinase regulator activity; cholecystokinin receptor activity; gastrin receptor activity; phosphoinositide phospholipase C activity; protein binding; type B gastrin/cholecystokinin receptor binding Biological Process: cell proliferation; cell surface receptor linked signal transduction; digestion; elevation of cytosolic calcium ion concentration; feeding behavior; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); gastric acid secretion; gland development; gut development; positive regulation of cell proliferation; regulation of phosphoinositide 3-kinase activity; sensory perception |
| NCBI Summary: | This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015] |
| UniProt Code: | P32239 |
| NCBI GenInfo Identifier: | 417029 |
| NCBI Gene ID: | 887 |
| NCBI Accession: | P32239.1 |
| UniProt Secondary Accession: | P32239,O75824, Q16144, Q92492, Q96LC6, Q9NYK7, Q9UBV1 A8K7P9, |
| UniProt Related Accession: | P32239 |
| Molecular Weight: | 41,504 Da |
| NCBI Full Name: | Gastrin/cholecystokinin type B receptor |
| NCBI Synonym Full Names: | cholecystokinin B receptor |
| NCBI Official Symbol: | CCKBR |
| NCBI Official Synonym Symbols: | GASR; CCK-B; CCK2R |
| NCBI Protein Information: | gastrin/cholecystokinin type B receptor |
| UniProt Protein Name: | Gastrin/cholecystokinin type B receptor |
| UniProt Synonym Protein Names: | Cholecystokinin-2 receptor; CCK2-R |
| Protein Family: | Gastrin/cholecystokinin type B receptor |
| UniProt Gene Name: | CCKBR |
| UniProt Entry Name: | GASR_HUMAN |
 | Western blot analysis of extracts of human stomach cancer tissue, using CCKBR antibody (CAB2941). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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