Anti-CACNA1B Antibody (CAB16687)
- SKU:
- CAB16687
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CACNA1B Antibody |
| Antibody SKU: | CAB16687 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 2200 to the C-terminus of human CACNA1B (NP_000709.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 2200 to the C-terminus of human CACNA1B (NP_000709.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SITY KTAN SSPI HFAG AQTS LPAF SPGR LSRG LSEH NALL QRDP LSQP LAPG SRIG SDPY LGQR LDSE ASVH ALPE DTLT FEEA VATN SGRS SRTS YVSS LTSQ SHPL RRVP NGYH CTLG LSSG GRAR HSYH HPDQ DHWC |
| Gene ID: | 774 |
| Uniprot: | Q00975 |
| Cellular Location: | |
| Calculated MW: | 251kDa/262kDa |
| Observed MW: | 262kDa |
| Synonyms: | CACNA1B, BIII, CACNL1A5, CACNN, Cav2.2, DYT23 |
| Background: | The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. |
| NCBI Summary: | The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q00975 |
| NCBI GenInfo Identifier: | 4502523 |
| NCBI Gene ID: | 774 |
| NCBI Accession: | NP_000709 |
| UniProt Related Accession: | Q00975 |
| Molecular Weight: | Predicted Molecular Mass: 25.1kDaAccurate Molecular Mass: 28kDa |
| NCBI Full Name: | voltage-dependent N-type calcium channel subunit alpha-1B isoform 1 |
| NCBI Synonym Full Names: | calcium voltage-gated channel subunit alpha1 B |
| NCBI Official Symbol: | CACNA1B |
| NCBI Official Synonym Symbols: | BIII; CACNN; DYT23; Cav2.2; NEDNEH; CACNL1A5 |
| NCBI Protein Information: | voltage-dependent N-type calcium channel subunit alpha-1B |
| UniProt Protein Name: | Voltage-dependent N-type calcium channel subunit alpha-1B |
| UniProt Synonym Protein Names: | Brain calcium channel III; BIII; Calcium channel, L type, alpha-1 polypeptide isoform 5; Voltage-gated calcium channel subunit alpha Cav2.2 |
| Protein Family: | GTP-binding protein |
| UniProt Gene Name: | CACNA1B |
| UniProt Entry Name: | CAC1B_HUMAN |
 | Western blot analysis of extracts of U-87MG cells, using CACNA1B antibody (CAB16687) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min. |
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