Anti-C6 Antibody (CAB10170)
- SKU:
- CAB10170
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| Antibody Name: | Anti-C6 Antibody |
| Antibody SKU: | CAB10170 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-260 of human C6 (NP_000056.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse liver, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-260 of human C6 (NP_000056.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | CFCD HYAW TQWT SCSK TCNS GTQS RHRQ IVVD KYYQ ENFC EQIC SKQE TREC NWQR CPIN CLLG DFGP WSDC DPCI EKQS KVRS VLRP SQFG GQPC TAPL VAFQ PCIP SKLC KIEE ADCK NKFR CDSG RCIA RKLE CNGE NDCG DNSD ERDC GRTK AVCT RKYN PIPS VQLM GNGF HFLA GEPR GEVL DNSF TGGI CKTV KSSR TSNP YRVP ANLE NVGF EVQT AEDD LKTD FYKD LTS |
| Gene ID: | 729 |
| Uniprot: | P13671 |
| Cellular Location: | Secreted |
| Calculated MW: | 104kDa |
| Observed MW: | 110kDa |
| Synonyms: | C6 |
| Background: | This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described. |
| UniProt Protein Function: | C6: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C6 are the cause of complement component 6 deficiency (C6D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 5p13.1 Cellular Component: extracellular region; membrane attack complex Molecular Function:protein binding Biological Process: complement activation; regulation of complement activation Disease: Complement Component 6 Deficiency |
| NCBI Summary: | This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012] |
| UniProt Code: | P13671 |
| NCBI GenInfo Identifier: | 146345396 |
| NCBI Gene ID: | 729 |
| NCBI Accession: | P13671.3 |
| UniProt Related Accession: | P13671 |
| Molecular Weight: | 104,786 Da |
| NCBI Full Name: | Complement component C6 |
| NCBI Synonym Full Names: | complement C6 |
| NCBI Official Symbol: | C6 |
| NCBI Protein Information: | complement component C6 |
| UniProt Protein Name: | Complement component C6 |
| Protein Family: | Complement component |
| UniProt Gene Name: | C6 |
 | Western blot analysis of extracts of various cell lines, using C6 antibody (CAB10170) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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