Anti-BMP5 Antibody (CAB8401)
- SKU:
- CAB8401
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-BMP5 Antibody |
| Antibody SKU: | CAB8401 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 317-454 of human BMP5 (NP_066551.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | H460, LO2, SW620, 293T, mouse liver, mouse small intestine, mouse skeletal muscle, rat lung, rat liver, NCI-H460, Mouse lung, Mouse liver, Mouse small intestine |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 317-454 of human BMP5 (NP_066551.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AANK RKNQ NRNK SSSH QDSS RMSS VGDY NTSE QKQA CKKH ELYV SFRD LGWQ DWII APEG YAAF YCDG ECSF PLNA HMNA TNHA IVQT LVHL MFPD HVPK PCCA PTKL NAIS VLYF DDSS NVIL KKYR NMVV RSCG CH |
| Gene ID: | 653 |
| Uniprot: | P22003 |
| Cellular Location: | Secreted |
| Calculated MW: | 47kDa/51kDa |
| Observed MW: | 52kDa |
| Synonyms: | BMP5 |
| Background: | This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors. |
| UniProt Protein Function: | BMP5: Induces cartilage and bone formation. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 6p12.1 Cellular Component: extracellular space Molecular Function:growth factor activity; cytokine activity; transforming growth factor beta receptor binding Biological Process: ossification; negative regulation of insulin-like growth factor receptor signaling pathway; pattern specification process; regulation of apoptosis; BMP signaling pathway; negative regulation of cell proliferation; cartilage development; regulation of MAPKKK cascade; negative regulation of aldosterone biosynthetic process; male genitalia development; positive regulation of transcription from RNA polymerase II promoter; skeletal development; positive regulation of epithelial cell proliferation; growth |
| NCBI Summary: | This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P22003 |
| NCBI GenInfo Identifier: | 115075 |
| NCBI Gene ID: | 653 |
| NCBI Accession: | P22003.1 |
| UniProt Secondary Accession: | P22003,Q9H547, Q9NTM5, B4E0Y4, |
| UniProt Related Accession: | P22003 |
| Molecular Weight: | 47,670 Da |
| NCBI Full Name: | Bone morphogenetic protein 5 |
| NCBI Synonym Full Names: | bone morphogenetic protein 5 |
| NCBI Official Symbol: | BMP5 |
| NCBI Protein Information: | bone morphogenetic protein 5; BMP-5; bone morphogenenic protein-5 |
| UniProt Protein Name: | Bone morphogenetic protein 5 |
| Protein Family: | Bone morphogenetic protein |
| UniProt Gene Name: | BMP5 |
| UniProt Entry Name: | BMP5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BMP5 antibody (CAB8401) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunohistochemistry of paraffin-embedded rat lung using BMP5 antibody (CAB8401) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human prostate using BMP5 antibody (CAB8401) at dilution of 1:100 (40x lens). |
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