Anti-BLVRB Antibody (CAB7260)
- SKU:
- CAB7260
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-BLVRB Antibody |
| Antibody SKU: | CAB7260 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-206 of human BLVRB (NP_000704.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, U-251MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-206 of human BLVRB (NP_000704.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAVK KIAI FGAT GQTG LTTL AQAV QAGY EVTV LVRD SSRL PSEG PRPA HVVV GDVL QAAD VDKT VAGQ DAVI VLLG TRND LSPT TVMS EGAR NIVA AMKA HGVD KVVA CTSA FLLW DPTK VPPR LQAV TDDH IRMH KVLR ESGL KYVA VMPP HIGD QPLT GAYT VTLD GRGP SRVI SKHD LGHF MLRC LTTD EYDG HSTY PSHQ YQ |
| Gene ID: | 645 |
| Uniprot: | P30043 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 22kDa |
| Observed MW: | 22KDa |
| Synonyms: | BLVRB, BVRB, FLR, HEL-S-10, SDR43U1 |
| Background: | The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009] |
| UniProt Protein Function: | BLVRB: Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. |
| UniProt Protein Details: | Protein type:EC 1.5.1.30; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Oxidoreductase; EC 1.3.1.24 Chromosomal Location of Human Ortholog: 19q13.1-q13.2 Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol Molecular Function:flavin reductase activity; biliverdin reductase activity Biological Process: heme catabolic process; porphyrin metabolic process |
| NCBI Summary: | The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009] |
| UniProt Code: | P30043 |
| NCBI GenInfo Identifier: | 1706870 |
| NCBI Gene ID: | 645 |
| NCBI Accession: | P30043.3 |
| UniProt Secondary Accession: | P30043,P32078, P53005, Q32LZ2, A6NKD8, B2R5C6, |
| UniProt Related Accession: | P30043 |
| Molecular Weight: | 206 |
| NCBI Full Name: | Flavin reductase (NADPH) |
| NCBI Synonym Full Names: | biliverdin reductase B |
| NCBI Official Symbol: | BLVRB |
| NCBI Official Synonym Symbols: | FLR; BVRB; SDR43U1; HEL-S-10 |
| NCBI Protein Information: | flavin reductase (NADPH); flavin reductase (NADPH); FR; GHBP; BVR-B; NADPH-flavin reductase; NADPH-dependent diaphorase; green heme-binding protein; biliverdin-IX beta-reductase; epididymis secretory protein Li 10; biliverdin reductase B (flavin reductase (NADPH)); short chain dehydrogenase/reductase family 43U, member 1 |
| UniProt Protein Name: | Flavin reductase (NADPH) |
| UniProt Synonym Protein Names: | Biliverdin reductase B (EC:1.3.1.24); BVR-B; Biliverdin-IX beta-reductase; Green heme-binding protein; GHBP; NADPH-dependent diaphorase; NADPH-flavin reductase; FLR |
| UniProt Gene Name: | BLVRB |
| UniProt Entry Name: | BLVRB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using BLVRB Rabbit pAb (CAB7260) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using BLVRB antibody (CAB7260) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using BLVRB antibody (CAB7260) at dilution of 1:100 (40x lens). |
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