Anti-ATP7A Antibody (CAB8399)
- SKU:
- CAB8399
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-ATP7A Antibody |
| Antibody SKU: | CAB8399 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human ATP7A (NP_000043.4). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Rat |
| Positive Samples: | 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human ATP7A (NP_000043.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDPS MGVN SVTI SVEG MTCN SCVW TIEQ QIGK VNGV HHIK VSLE EKNA TIIY DPKL QTPK TLQE AIDD MGFD AVIH NPDP LPVL TDTL FLTV TASL TLPW DHIQ STLL KTKG VTDI KIYP QKRT VAVT IIPS IVNA NQIK ELVP ELSL DTGT LEKK SGAC EDHS MAQA GE |
| Gene ID: | 538 |
| Uniprot: | Q04656 |
| Cellular Location: | Cell membrane, Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Multi-pass membrane protein, Multi-pass membrane protein, cytosol, trans-Golgi network membrane |
| Calculated MW: | 11kDa/54kDa/154kDa/163kDa/165kDa/172kDa |
| Observed MW: | 163kDa |
| Synonyms: | ATP7A, DSMAX, MK, MNK, SMAX3 |
| Background: | This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed. |
| UniProt Protein Function: | May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells. |
| NCBI Summary: | This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q04656 |
| NCBI GenInfo Identifier: | 223590241 |
| NCBI Gene ID: | 538 |
| NCBI Accession: | Q04656.3 |
| UniProt Secondary Accession: | Q04656,O00227, O00745, Q9BYY8, B1AT72, |
| UniProt Related Accession: | Q04656 |
| Molecular Weight: | 11,522 Da |
| NCBI Full Name: | Copper-transporting ATPase 1 |
| NCBI Synonym Full Names: | ATPase copper transporting alpha |
| NCBI Official Symbol: | ATP7A |
| NCBI Official Synonym Symbols: | MK; MNK; DSMAX; SMAX3 |
| NCBI Protein Information: | copper-transporting ATPase 1 |
| UniProt Protein Name: | Copper-transporting ATPase 1 |
| UniProt Synonym Protein Names: | Copper pump 1; Menkes disease-associated protein |
| UniProt Gene Name: | ATP7A |
| UniProt Entry Name: | ATP7A_HUMAN |
 | Western blot analysis of extracts of 293T cells, using ATP7A antibody (CAB8399) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using ATP7A antibody (CAB8399) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver damage using ATP7A antibody (CAB8399) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using ATP7A antibody (CAB8399) at dilution of 1:100 (40x lens). |
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