Anti-ATL3 Antibody (CAB12196)
- SKU:
- CAB12196
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-ATL3 Antibody |
| Antibody SKU: | CAB12196 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 360-440 of human ATL3 (NP_056274.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 360-440 of human ATL3 (NP_056274.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KDIY YNNM EEVC GGEK PYLS PDIL EEKH CEFK QLAL DHFK KTKK MGGK DFSF RYQQ ELEE EIKE LYEN FCKH NGSK NVFS T |
| Gene ID: | 25923 |
| Uniprot: | Q6DD88 |
| Cellular Location: | Endoplasmic reticulum membrane, Multi-pass membrane protein |
| Calculated MW: | 60kDa |
| Observed MW: | 50-60kDa |
| Synonyms: | ATL3, HSN1F |
| Background: | This gene encodes a member of a family of dynamin-like, integral membrane GTPases. The encoded protein is required for the proper formation of the network of interconnected tubules of the endoplasmic reticulum. Mutations in this gene may be associated with hereditary sensory neuropathy type IF. Alternatively spliced transcript variants that encode distinct isoforms have been described. |
| UniProt Protein Function: | ATL3: GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. Belongs to the GBP family. Atlastin subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; EC 3.6.5.-; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 11q13.1 Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane Molecular Function:GTPase activity; identical protein binding; GTP binding Biological Process: endoplasmic reticulum organization and biogenesis; ER to Golgi vesicle-mediated transport; metabolic process; Golgi organization and biogenesis; protein homooligomerization Disease: Neuropathy, Hereditary Sensory, Type If |
| NCBI Summary: | This gene encodes a member of a family of dynamin-like, integral membrane GTPases. The encoded protein is required for the proper formation of the network of interconnected tubules of the endoplasmic reticulum. Mutations in this gene may be associated with hereditary sensory neuropathy type IF. Alternatively spliced transcript variants that encode distinct isoforms have been described. [provided by RefSeq, Feb 2014] |
| UniProt Code: | Q6DD88 |
| NCBI GenInfo Identifier: | 74736374 |
| NCBI Gene ID: | 25923 |
| NCBI Accession: | Q6DD88.1 |
| UniProt Secondary Accession: | Q6DD88,Q8N7W5, Q9H8Q5, Q9UFL1, |
| UniProt Related Accession: | Q6DD88 |
| Molecular Weight: | 541 |
| NCBI Full Name: | Atlastin-3 |
| NCBI Synonym Full Names: | atlastin GTPase 3 |
| NCBI Official Symbol: | ATL3 |
| NCBI Official Synonym Symbols: | HSN1F |
| NCBI Protein Information: | atlastin-3 |
| UniProt Protein Name: | Atlastin-3 |
| Protein Family: | Atlastin |
| UniProt Gene Name: | ATL3 |
| UniProt Entry Name: | ATLA3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ATL3 antibody (CAB12196) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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