Anti-ARAP2 Antibody (CAB12254)
- SKU:
- CAB12254
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-ARAP2 Antibody |
| Antibody SKU: | CAB12254 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1405-1704 of human ARAP2 (NP_056045.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, K-562, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1405-1704 of human ARAP2 (NP_056045.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LAEP GSAY LVVK RFLT ADTI KHCS DRST LGSI KEGI LKIK EEPS KILS GNKF QDRY FVLR DGFL FLYK DVKS SKHD KMFS LSSM KFYR GVKK KMKP PTSW GLTA YSEK HHWH LCCD SSRT QTEW MTSI FIAQ HEYD IWPP AGKE RKRS ITKN PKIG GLPL IPIQ HEGN ATLA RKNI ESAR AELE RLRL SEKC DKES VDSS LKER ASMV AHCL EHKD DKLR NRPR KHRS FNCL EDTE PEAP LGQP KGHK GLKT LRKT EDRN SKAT LDSD HKLP SRVI EELN VVLQ RSRT LPKE LQDE QILK |
| Gene ID: | 116984 |
| Uniprot: | Q8WZ64 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 193kDa |
| Observed MW: | 170kDa |
| Synonyms: | ARAP2, CENTD1, PARX |
| Background: | The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3, 4, 5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. |
| UniProt Protein Function: | CENTD1: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. |
| UniProt Protein Details: | Protein type:GAP; GAP, ARF Chromosomal Location of Human Ortholog: 4p14 Cellular Component: cytosol Molecular Function:GTPase activator activity; phosphatidylinositol-3,4,5-triphosphate binding Biological Process: regulation of small GTPase mediated signal transduction |
| NCBI Summary: | The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008] |
| UniProt Code: | Q8WZ64 |
| NCBI GenInfo Identifier: | 308153629 |
| NCBI Gene ID: | 116984 |
| NCBI Accession: | Q8WZ64.3 |
| UniProt Secondary Accession: | Q8WZ64,Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4, |
| UniProt Related Accession: | Q8WZ64 |
| Molecular Weight: | Observed MW 170kDaCalculated MW 193kDa |
| NCBI Full Name: | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 |
| NCBI Synonym Full Names: | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
| NCBI Official Symbol: | ARAP2 |
| NCBI Official Synonym Symbols: | PARX; CENTD1 |
| NCBI Protein Information: | arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 |
| UniProt Protein Name: | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 |
| UniProt Synonym Protein Names: | Centaurin-delta-1; Cnt-d1; Protein PARX |
| Protein Family: | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein |
| UniProt Gene Name: | ARAP2 |
 | Western blot analysis of extracts of various cell lines, using ARAP2 antibody (CAB12254) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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