Anti-AOC1 Antibody (CAB6249)
- SKU:
- CAB6249
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-AOC1 Antibody |
| Antibody SKU: | CAB6249 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human AOC1 (NP_001082.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse kidney, Mouse liver, Mouse heart, Rat kidney, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human AOC1 (NP_001082.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EPSP GTLP RKAG VFSD LSNQ ELKA VHSF LWSK KELR LQPS STTT MAKN TVFL IEML LPKK YHVL RFLD KGER HPVR EARA VIFF GDQE HPNV TEFA VGPL PGPC YMRA LSPR PGYQ SSWA SRPI STAE YALL YHTL QEAT KPLH QFFL NTTG FSFQ DCHD RCLA FTDV APRG VASG QRRS WLII QRYV EGYF LHPT GLEL LVDH GSTD AGHW AVEQ VWYN GKFY GSPE ELAR KYAD GEVD VVVL EDPL PGGK GHDS TEEP PLFS SHKP RGDF PSPI HVSG P |
| Gene ID: | 26 |
| Uniprot: | P19801 |
| Cellular Location: | Secreted, extracellular space |
| Calculated MW: | 85kDa/87kDa |
| Observed MW: | 105kDa |
| Synonyms: | AOC1, ABP, ABP1, DAO, DAO1, KAO |
| Background: | This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | ABP1: Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function. Belongs to the copper/topaquinone oxidase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - arginine and proline; Secreted; Amino Acid Metabolism - tryptophan; Oxidoreductase; Secreted, signal peptide; EC 1.4.3.22; Amino Acid Metabolism - histidine Chromosomal Location of Human Ortholog: 7q36.1 Cellular Component: extracellular space; tight junction; plasma membrane; peroxisome Molecular Function:amine oxidase activity; heparin binding; copper ion binding; protein homodimerization activity; zinc ion binding; protein complex binding; calcium ion binding; receptor activity; cation channel activity; drug binding; sodium channel activity; quinone binding Biological Process: response to antibiotic; response to drug; amine metabolic process |
| NCBI Summary: | This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013] |
| UniProt Code: | P19801 |
| NCBI GenInfo Identifier: | 251757489 |
| NCBI Gene ID: | 26 |
| NCBI Accession: | P19801.4 |
| UniProt Secondary Accession: | P19801,Q16683, Q16684, Q56II4, Q6GU42, C9J690, |
| UniProt Related Accession: | P19801 |
| Molecular Weight: | 87,239 Da |
| NCBI Full Name: | Amiloride-sensitive amine oxidase |
| NCBI Synonym Full Names: | amine oxidase, copper containing 1 |
| NCBI Official Symbol: | AOC1 |
| NCBI Official Synonym Symbols: | ABP; DAO; KAO; ABP1; DAO1 |
| NCBI Protein Information: | amiloride-sensitive amine oxidase [copper-containing]; amiloride-sensitive amine oxidase [copper-containing]; amiloride binding protein 1 (amine oxidase (copper-containing)); amiloride-binding protein 1; amine oxidase copper domain-containing protein 1; diamine oxidase; histaminase; kidney amine oxidase |
| UniProt Protein Name: | Amiloride-sensitive amine oxidase [copper-containing] |
| UniProt Synonym Protein Names: | Amiloride-binding protein 1; Amine oxidase copper domain-containing protein 1; Histaminase; Kidney amine oxidase; KAO |
| Protein Family: | D-amino-acid oxidase |
| UniProt Gene Name: | AOC1 |
| UniProt Entry Name: | AOC1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AOC1 antibody (CAB6249) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of HeLa cells using AOC1 Polyclonal Antibody (CAB6249) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of NIH-3T3 cells using AOC1 Polyclonal Antibody (CAB6249) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of PC-12 cells using AOC1 Polyclonal Antibody (CAB6249) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
Related Products
Human ABP1 / AOC1 ELISA Kit
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
Human Anti-DSG3 antibody(anti-Desmoglein-3 antibody) ELISA Kit
