Anti-ALDH3A1 Antibody (CAB5502)
- SKU:
- CAB5502
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-ALDH3A1 Antibody |
| Antibody SKU: | CAB5502 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ALDH3A1 (NP_001128640.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, NCI-H460, HT-29, HeLa, Mouse lung, Mouse testis, Mouse stomach, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ALDH3A1 (NP_001128640.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSKI SEAV KRAR AAFS SGRT RPLQ FRIQ QLEA LQRL IQEQ EQEL VGAL AADL HKNE WNAY YEEV VYVL EEIE YMIQ KLPE WAAD EPVE KTPQ TQQD ELYI HSEP LGVV LVIG TWNY PFNL TIQP MVGA IAAG NSVV LKPS ELSE NMAS LLAT IIPQ YLDK DLYP VING GVPE TTEL LKER FDHI LYTG STGV GKII MTAA AKHL TPVT LELG GKSP CYVD KNCD LDVA CRRI AWGK FMNS GQTC VAPD YILC DPSI QNQI VEKL KKSL KEFY GEDA KKSR DYGR IISA RHFQ RVMG LIEG |
| Gene ID: | 218 |
| Uniprot: | P30838 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 50kDa |
| Observed MW: | 55kDa |
| Synonyms: | ALDH3A1, ALDH3, ALDHIII |
| Background: | Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
| UniProt Protein Function: | ALDH3A1: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes. Belongs to the aldehyde dehydrogenase family. |
| UniProt Protein Details: | Protein type:Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - phenylalanine; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.5; Amino Acid Metabolism - histidine; Xenobiotic Metabolism - metabolism by cytochrome P450; Amino Acid Metabolism - tyrosine; Oxidoreductase Chromosomal Location of Human Ortholog: 17p11.2 Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; extracellular space; intracellular membrane-bound organelle; nucleoplasm; plasma membrane Molecular Function:3-chloroallyl aldehyde dehydrogenase activity; alcohol dehydrogenase (NADP+) activity; aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; benzaldehyde dehydrogenase (NAD+) activity; protein binding Biological Process: aldehyde metabolic process; xenobiotic metabolic process |
| NCBI Summary: | Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008] |
| UniProt Code: | P30838 |
| NCBI GenInfo Identifier: | 311033473 |
| NCBI Gene ID: | 218 |
| NCBI Accession: | P30838.3 |
| UniProt Secondary Accession: | P30838,Q9BT37, A8K828, |
| UniProt Related Accession: | P30838 |
| Molecular Weight: | 50,395 Da |
| NCBI Full Name: | Aldehyde dehydrogenase, dimeric NADP-preferring |
| NCBI Synonym Full Names: | aldehyde dehydrogenase 3 family member A1 |
| NCBI Official Symbol: | ALDH3A1 |
| NCBI Official Synonym Symbols: | ALDH3; ALDHIII |
| NCBI Protein Information: | aldehyde dehydrogenase, dimeric NADP-preferring |
| UniProt Protein Name: | Aldehyde dehydrogenase, dimeric NADP-preferring |
| UniProt Synonym Protein Names: | ALDHIII; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase family 3 member A1 |
| Protein Family: | Aldehyde dehydrogenase |
| UniProt Gene Name: | ALDH3A1 |
| UniProt Entry Name: | AL3A1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ALDH3A1 antibody (CAB5502) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunofluorescence analysis of U2OS cells using ALDH3A1 antibody (CAB5502). Blue: DAPI for nuclear staining. |
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