Anti-ADRBK2 Antibody (CAB2049)
- SKU:
- CAB2049
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-ADRBK2 Antibody |
| Antibody SKU: | CAB2049 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ADRBK2 (NP_005151.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, SH-SY5Y, Mouse lung, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ADRBK2 (NP_005151.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MADL EAVL ADVS YLMA MEKS KATP AARA SKRI VLPE PSIR SVMQ KYLA ERNE ITFD KIFN QKIG FLLF KDFC LNEI NEAV PQVK FYEE IKEY EKLD NEED RLCR SRQI YDAY IMKE LLSC SHPF SKQA VEHV QSHL SKKQ VTST LFQP YIEE ICES LRGD IFQK FMES DKFT RFCQ WKNV ELNI HLTM NEFS VHRI IGRG GFGE VYGC RKAD TGKM YAMK CLDK KRIK MKQG ETLA LNER IMLS LVST GDCP FIVC MTYA FHTP DKLC FILD LMNG GDLH YHLS QHGV FSEK EMRF YATE |
| Gene ID: | 157 |
| Uniprot: | P35626 |
| Cellular Location: | |
| Calculated MW: | 79kDa |
| Observed MW: | 100kDa |
| Synonyms: | GRK3, ADRBK2, BARK2 |
| Background: | The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. |
| UniProt Protein Function: | GRK3: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; EC 2.7.11.15; Kinase, protein; AGC group; GRK family; BARK subfamily Chromosomal Location of Human Ortholog: 22q12.1 Molecular Function:ATP binding; beta-adrenergic receptor kinase activity; G-protein coupled receptor kinase activity; protein kinase activity Biological Process: protein amino acid phosphorylation; receptor internalization; signal transduction |
| NCBI Summary: | The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P35626 |
| NCBI GenInfo Identifier: | 116241253 |
| NCBI Gene ID: | 157 |
| NCBI Accession: | P35626.2 |
| UniProt Secondary Accession: | P35626,Q9UGW9, |
| UniProt Related Accession: | P35626 |
| Molecular Weight: | 79,710 Da |
| NCBI Full Name: | Beta-adrenergic receptor kinase 2 |
| NCBI Synonym Full Names: | adrenergic, beta, receptor kinase 2 |
| NCBI Official Symbol: | ADRBK2 |
| NCBI Official Synonym Symbols: | GRK3; BARK2 |
| NCBI Protein Information: | beta-adrenergic receptor kinase 2 |
| UniProt Protein Name: | Beta-adrenergic receptor kinase 2 |
| UniProt Synonym Protein Names: | G-protein-coupled receptor kinase 3 |
| Protein Family: | Beta-adrenergic receptor kinase |
| UniProt Gene Name: | ADRBK2 |
| UniProt Entry Name: | ARBK2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ADRBK2 antibody (CAB2049) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 45s. |
 | Immunohistochemistry of paraffin-embedded rat spinal cord using ADRBK2 Antibody (CAB2049) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using ADRBK2 Antibody (CAB2049) at dilution of 1:100 (40x lens). |
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