Anti-ADH1B Antibody (CAB1431)
- SKU:
- CAB1431
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-ADH1B Antibody |
| Antibody SKU: | CAB1431 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 206-375 of human ADH1B (NP_000659.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 206-375 of human ADH1B (NP_000659.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LSAV MGCK AAGA ARII AVDI NKDK FAKA KELG ATEC INPQ DYKK PIQE VLKE MTDG GVDF SFEV IGRL DTMM ASLL CCHE ACGT SVIV GVPP ASQN LSIN PMLL LTGR TWKG AVYG GFKS KEGI PKLV ADFM AKKF SLDA LITH VLPF EKIN EGFD LLHS GKSI RTVL TF |
| Gene ID: | 125 |
| Uniprot: | P00325 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 35kDa/39kDa |
| Observed MW: | 40kDa |
| Synonyms: | ADH1B, ADH2, HEL-S-117 |
| Background: | The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ADH1B: Dimer of identical or non-identical chains of three types; alpha, beta and gamma. Belongs to the zinc-containing alcohol dehydrogenase family. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - fatty acid; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.1.1.1; Oxidoreductase; Amino Acid Metabolism - tyrosine; Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - drug metabolism - cytochrome P450 Chromosomal Location of Human Ortholog: 4q23 Cellular Component: cytosol Molecular Function:zinc ion binding; alcohol dehydrogenase activity, zinc-dependent Biological Process: xenobiotic metabolic process; ethanol oxidation Disease: Alcohol Dependence |
| NCBI Summary: | The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] |
| UniProt Code: | P00325 |
| NCBI GenInfo Identifier: | 113394 |
| NCBI Gene ID: | 125 |
| NCBI Accession: | P00325.2 |
| UniProt Secondary Accession: | P00325,Q13711, Q4ZGI9, Q96KI7, A8MYN5, B4DRS9, B4DVC3 |
| UniProt Related Accession: | P00325 |
| Molecular Weight: | 375 |
| NCBI Full Name: | Alcohol dehydrogenase 1B |
| NCBI Synonym Full Names: | alcohol dehydrogenase 1B (class I), beta polypeptide |
| NCBI Official Symbol: | ADH1B |
| NCBI Official Synonym Symbols: | ADH2; HEL-S-117 |
| NCBI Protein Information: | alcohol dehydrogenase 1B; ADH, beta subunit; aldehyde reductase; alcohol dehydrogenase subunit beta; epididymis secretory protein Li 117; alcohol dehydrogenase 2 (class I), beta polypeptide |
| UniProt Protein Name: | Alcohol dehydrogenase 1B |
| UniProt Synonym Protein Names: | Alcohol dehydrogenase subunit beta |
| Protein Family: | Alcohol dehydrogenase |
| UniProt Gene Name: | ADH1B |
| UniProt Entry Name: | ADH1B_HUMAN |
 | Western blot analysis of extracts of rat liver, using ADH1B antibody (CAB1431) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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