Anti-ADCY2 Antibody (CAB9805)
- SKU:
- CAB9805
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-ADCY2 Antibody |
| Antibody SKU: | CAB9805 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 430-600 of human ADCY2 (NP_065433.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, Rat eye |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 430-600 of human ADCY2 (NP_065433.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VTLE HLNG AYKV EEGD GDIR DPYL KQHL VKTY FVIN PKGE RRSP QHLF RPRH TLDG AKMR ASVR MTRY LESW GAAK PFAH LHHR DSMT TENG KIST TDVP MGQH NFQN RTLR TKSQ KKRF EEEL NERM IQAI DGIN AQKQ WLKS EDIQ RISL LFYN KVLE KEYR ATAL PAF |
| Gene ID: | 108 |
| Uniprot: | Q08462 |
| Cellular Location: | Cell membrane, Cytoplasm, Membrane, Multi-pass membrane protein |
| Calculated MW: | 103kDa/123kDa |
| Observed MW: | 150kDa |
| Synonyms: | ADCY2, AC2, HBAC2 |
| Background: | This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. |
| UniProt Protein Function: | ADCY2: This is a membrane-bound, calmodulin-insensitive adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Adenylyl cyclase; Transporter, aquaporin family; Nucleotide Metabolism - purine; Membrane protein, multi-pass; EC 4.6.1.1; Transporter; Lyase Chromosomal Location of Human Ortholog: 5p15.3 Cellular Component: cytoplasm; dendrite; integral to plasma membrane; intracellular; lipid raft; membrane; plasma membrane Molecular Function:adenylate cyclase activity; adenylate cyclase binding; magnesium ion binding; manganese ion binding; protein heterodimerization activity Biological Process: activation of protein kinase A; adenylate cyclase activation; cAMP biosynthetic process; cAMP-mediated signaling; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; renal water homeostasis |
| NCBI Summary: | This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q08462 |
| NCBI GenInfo Identifier: | 118572617 |
| NCBI Gene ID: | 108 |
| NCBI Accession: | Q08462.5 |
| UniProt Secondary Accession: | Q08462,Q2NKL8, Q9UDB2, Q9UPU2, B7Z2C1, |
| UniProt Related Accession: | Q08462 |
| Molecular Weight: | 103,158 Da |
| NCBI Full Name: | Adenylate cyclase type 2 |
| NCBI Synonym Full Names: | adenylate cyclase 2 |
| NCBI Official Symbol: | ADCY2 |
| NCBI Official Synonym Symbols: | AC2; HBAC2 |
| NCBI Protein Information: | adenylate cyclase type 2 |
| UniProt Protein Name: | Adenylate cyclase type 2 |
| UniProt Synonym Protein Names: | ATP pyrophosphate-lyase 2; Adenylate cyclase type II; Adenylyl cyclase 2 |
| Protein Family: | Adenylate cyclase |
| UniProt Gene Name: | ADCY2 |
| UniProt Entry Name: | ADCY2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ADCY2 antibody (CAB9805) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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