Anti-ADAM8 Antibody (CAB10497)
- SKU:
- CAB10497
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ADAM8 Antibody |
| Antibody SKU: | CAB10497 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-300 of human ADAM8 (NP_001100.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BxPC-3, NIH/3T3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-300 of human ADAM8 (NP_001100.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IAPS RPWA LMEQ YEVV LPWR LPGP RVRR ALPS HLGL HPER VSYV LGAT GHNF TLHL RKNR DLLG SGYT ETYT AANG SEVT EQPR GQDH CFYQ GHVE GYPD SAAS LSTC AGLR GFFQ VGSD LHLI EPLD EGGE GGRH AVYQ AEHL LQTA GTCG VSDD SLGS LLGP RTAA VFRP RPGD SLPS RETR YVEL YVVV DNAE FQML GSEA AVRH RVLE VVNH VDKL YQKL NFRV VLVG LEIW NSQD RFHV SPDP SVTL ENLL TWQA RQRT RRHL HDNV QLIT GVDF TGTT |
| Gene ID: | 101 |
| Uniprot: | P78325 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 78kDa/80kDa/88kDa |
| Observed MW: | 80kDa |
| Synonyms: | ADAM8, CD156, CD156a, MS2 |
| Background: | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | ADAM8: Possible involvement in extravasation of leukocytes. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; EC 3.4.24.-; Protease; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 10q26.3 Cellular Component: cell surface; cytoplasm; dense core granule membrane; integral to plasma membrane; plasma membrane; podosome; specific granule Molecular Function:calcium ion binding; cell adhesion molecule binding; metallopeptidase activity; protein binding; protein self-association; serine-type endopeptidase activity; zinc ion binding Biological Process: activation of NF-kappaB transcription factor; angiogenesis; cell morphogenesis; extracellular matrix disassembly; inflammatory response; leukocyte migration during inflammatory response; lymphocyte chemotaxis; negative regulation of neuron apoptosis; positive regulation of acute inflammatory response; positive regulation of bone resorption; positive regulation of cell adhesion; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein kinase B signaling cascade; positive regulation of protein secretion; positive regulation of T cell differentiation in the thymus; regulation of cell-cell adhesion |
| NCBI Summary: | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009] |
| UniProt Code: | P78325 |
| NCBI GenInfo Identifier: | 408359955 |
| NCBI Gene ID: | 101 |
| NCBI Accession: | P78325.2 |
| UniProt Secondary Accession: | P78325,B4DVM6, H0YL36, H0YLR0, H0YN39, |
| UniProt Related Accession: | P78325 |
| Molecular Weight: | 80,262 Da |
| NCBI Full Name: | Disintegrin and metalloproteinase domain-containing protein 8 |
| NCBI Synonym Full Names: | ADAM metallopeptidase domain 8 |
| NCBI Official Symbol: | ADAM8 |
| NCBI Official Synonym Symbols: | MS2; CD156; CD156a |
| NCBI Protein Information: | disintegrin and metalloproteinase domain-containing protein 8 |
| UniProt Protein Name: | Disintegrin and metalloproteinase domain-containing protein 8 |
| UniProt Synonym Protein Names: | Cell surface antigen MS2; CD_antigen: CD156a |
| Protein Family: | Disintegrin and metalloproteinase domain-containing protein |
| UniProt Gene Name: | ADAM8 |
| UniProt Entry Name: | ADAM8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ADAM8 antibody (CAB10497) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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