Anti-ACTR1A Antibody (CAB6515)
- SKU:
- CAB6515
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-ACTR1A Antibody |
| Antibody SKU: | CAB6515 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 187-376 of human ACTR1A (NP_005727.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, Mouse skeletal muscle, Mouse spleen, Mouse lung, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 187-376 of human ACTR1A (NP_005727.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GRDV SRFL RLYL RKEG YDFH SSSE FEIV KAIK ERAC YLSI NPQK DETL ETEK AQYY LPDG STIE IGPS RFRA PELL FRPD LIGE ESEG IHEV LVFA IQKS DMDL RRTL FSNI VLSG GSTL FKGF GDRL LSEV KKLA PKDV KIRI SAPQ ERLY STWI GGSI LASL DTFK KMWV SKKE YEED GARS IHRK TF |
| Gene ID: | 10121 |
| Uniprot: | P61163 |
| Cellular Location: | Cytoplasm, centrosome, cytoskeleton, microtubule organizing center |
| Calculated MW: | 42kDa |
| Observed MW: | 43kDa |
| Synonyms: | ACTR1A, ARP1, Arp1A, CTRN1 |
| Background: | This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. |
| UniProt Protein Function: | ACTR1A: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. Belongs to the actin family. ARP1 subfamily. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 10q24.32 Cellular Component: centrosome; cytoplasm; cytosol; microtubule associated complex; microtubule cytoskeleton Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; G2/M transition of mitotic cell cycle; vesicle-mediated transport |
| NCBI Summary: | This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P61163 |
| NCBI GenInfo Identifier: | 47117651 |
| NCBI Gene ID: | 10121 |
| NCBI Accession: | P61163.1 |
| UniProt Secondary Accession: | P61163,P42024, B2R6B0, |
| UniProt Related Accession: | P61163,AAB23391 |
| Molecular Weight: | 42,614 Da |
| NCBI Full Name: | Alpha-centractin |
| NCBI Synonym Full Names: | ARP1 actin-related protein 1 homolog A, centractin alpha |
| NCBI Official Symbol: | ACTR1A |
| NCBI Official Synonym Symbols: | ARP1; Arp1A; CTRN1 |
| NCBI Protein Information: | alpha-centractin |
| UniProt Protein Name: | Alpha-centractin |
| UniProt Synonym Protein Names: | ARP1; Actin-RPV; Centrosome-associated actin homolog |
| Protein Family: | Alpha-centractin |
| UniProt Gene Name: | ACTR1A |
| UniProt Entry Name: | ACTZ_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ACTR1A antibody (CAB6515) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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