ANP32E Antibody (PACO19921)
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주문- SKU:
- PACO19921
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ANP32E Antibody (PACO19921) |
Antibody SKU: | PACO19921 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human ANP32E |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19921(ANP32E Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse thymus tissue, Primary antibody: PACO19921(ANP32E Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO19921(ANP32E Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The Anp32 family consists of 32 evolutionarily-conserved proteins and is included within the superfamily of leucine-rich repeat (LRR) proteins. Leucine-rich acid, c nuclear protein-like (LANPL), also called ANP32E or Cpd1, is a member of the Anp32 family. LANPL is located in the cytoplasm of peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney. It has also been detected in the nucleus, cytoplasm and membrane of multiple brain regions. Upon phosphorylation, LANPL colocalizes and inhibits protein phosphatase 2A (PP2A), but does not inhibit PP1. LANPL modulates cell signalling and transduction of gene expression to regulate the morphology and dynamics of the cytoskeleton, cell adhesion, neural development and cerebellar morphogenesis. |
Synonyms: | acid, c (leucine-rich) nuclear phosphoprotein 32 family, member E |
UniProt Protein Function: | LANP-L: Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis process by modulating PP2A activity. Belongs to the ANP32 family. |
UniProt Protein Details: | Protein type:Vesicle; Protein phosphatase, regulatory subunit; Motility/polarity/chemotaxis; Inhibitor Chromosomal Location of Human Ortholog: 1q21.2 Cellular Component: cytoplasmic membrane-bound vesicle; nucleus Molecular Function:histone binding; phosphatase inhibitor activity Biological Process: histone exchange |
UniProt Code: | Q9BTT0 |
NCBI GenInfo Identifier: | 30580363 |
NCBI Gene ID: | 81611 |
NCBI Accession: | Q9BTT0.1 |
UniProt Secondary Accession: | Q9BTT0,Q5TB18, Q5TB20, Q8N1S4, Q8WWW9, B4E0I6, E9PEA6 |
UniProt Related Accession: | Q9BTT0 |
Molecular Weight: | 25,125 Da |
NCBI Full Name: | Acidic leucine-rich nuclear phosphoprotein 32 family member E |
NCBI Synonym Full Names: | acidic nuclear phosphoprotein 32 family member E |
NCBI Official Symbol: | ANP32E |
NCBI Official Synonym Symbols: | LANPL; LANP-L |
NCBI Protein Information: | acidic leucine-rich nuclear phosphoprotein 32 family member E |
UniProt Protein Name: | Acidic leucine-rich nuclear phosphoprotein 32 family member E |
UniProt Synonym Protein Names: | LANP-like protein; LANP-L |
Protein Family: | Acidic leucine-rich nuclear phosphoprotein 32 family |
UniProt Gene Name: | ANP32E |
UniProt Entry Name: | AN32E_HUMAN |