ANO6 Antibody (PACO59097)
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주문- SKU:
- PACO59097
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ANO6 Antibody (PACO59097) |
Antibody SKU: | PACO59097 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Anoctamin-6 protein (12-100AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunofluorescence staining of HepG2 cells with PACO59097 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. |
Synonyms: | Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F), ANO6, TMEM16F |
UniProt Protein Function: | Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. |
NCBI Summary: | This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011] |
UniProt Code: | Q4KMQ2 |
NCBI GenInfo Identifier: | 218156299 |
NCBI Gene ID: | 196527 |
NCBI Accession: | NP_001020527.2 |
UniProt Secondary Accession: | Q4KMQ2,Q8N3Q2, A6NNM6, B9EGG0, E7ENK4, E9PB30, E9PCT2 |
UniProt Related Accession: | Q4KMQ2 |
Molecular Weight: | 108,102 Da |
NCBI Full Name: | anoctamin-6 isoform a |
NCBI Synonym Full Names: | anoctamin 6 |
NCBI Official Symbol: | ANO6 |
NCBI Official Synonym Symbols: | SCTS; BDPLT7; TMEM16F |
NCBI Protein Information: | anoctamin-6 |
UniProt Protein Name: | Anoctamin-6 |
UniProt Synonym Protein Names: | Small-conductance calcium-activated nonselective cation channel; SCAN channel; Transmembrane protein 16F |
Protein Family: | Anoctamin |
UniProt Gene Name: | ANO6 |
Antibodies |
Anti-ANO6 Antibody (CAB12050) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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