AMOTL2 Antibody (PACO62063)
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주문- SKU:
- PACO62063
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | AMOTL2 Antibody (PACO62063) |
Antibody SKU: | PACO62063 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
Species Reactivity: | Human |
Immunogen: | Peptide sequence from Human Angiomotin-like protein 2 protein (718-737AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: 293T whole cell lysate, U251 whole cell lysate, HepG2 whole cell lysate, 293 whole cell lysate, A549 whole cell lysate, MCF-7 whole cell lysate, PC3 whole cell lysate. All lanes: AMOTL2 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 86, 92 kDa. Observed band size: 86 kDa. |
Background: | Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. |
Synonyms: | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP), AMOTL2, KIAA0989 |
UniProt Protein Function: | AMOTL2: Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. Belongs to the angiomotin family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell adhesion Chromosomal Location of Human Ortholog: 3q21-q22 Cellular Component: cytosol Molecular Function:protein binding |
NCBI Summary: | Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] |
UniProt Code: | Q9Y2J4 |
NCBI GenInfo Identifier: | 308153633 |
NCBI Gene ID: | 51421 |
NCBI Accession: | Q9Y2J4.3 |
UniProt Secondary Accession: | Q9Y2J4,Q53EP1, Q96F99, Q9UKB4, A8K6F1, B7Z5Q1, E9PHW3 |
UniProt Related Accession: | Q9Y2J4 |
Molecular Weight: | 91,817 Da |
NCBI Full Name: | Angiomotin-like protein 2 |
NCBI Synonym Full Names: | angiomotin like 2 |
NCBI Official Symbol: | AMOTL2 |
NCBI Official Synonym Symbols: | LCCP |
NCBI Protein Information: | angiomotin-like protein 2 |
UniProt Protein Name: | Angiomotin-like protein 2 |
UniProt Synonym Protein Names: | Leman coiled-coil protein; LCCP |
Protein Family: | Angiomotin-like protein |
UniProt Gene Name: | AMOTL2 |
UniProt Entry Name: | AMOL2_HUMAN |