ALG2 Antibody (PACO15389)
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주문- SKU:
- PACO15389
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | ALG2 Antibody (PACO15389) |
Antibody SKU: | PACO15389 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human ALG2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15389(ALG2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15389(ALG2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an α 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants. |
Synonyms: | ALG2, alpha-1,3/1,6-mannosyltransferase |
UniProt Protein Function: | ALG2: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate. Defects in ALG2 are the cause of congenital disorder of glycosylation type 1I (CDG1I). CDGs are a family of severe inherited diseases caused by a defect in protein N- glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 2.4.1.257; Transferase; Membrane protein, integral; Glycan Metabolism - N-glycan biosynthesis; EC 2.4.1.132 Chromosomal Location of Human Ortholog: 9q22.33 Cellular Component: cytoplasm; endoplasmic reticulum membrane; membrane; nucleus; perinuclear region of cytoplasm Molecular Function:alpha-1,3-mannosyltransferase activity; calcium-dependent protein binding; protein binding; protein heterodimerization activity; protein N-terminus binding Biological Process: dolichol-linked oligosaccharide biosynthetic process; protein amino acid glycosylation in endoplasmic reticulum; response to calcium ion Disease: Congenital Disorder Of Glycosylation, Type Ii; Myasthenic Syndrome, Congenital, With Tubular Aggregates 3 |
NCBI Summary: | This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008] |
UniProt Code: | Q9H553 |
NCBI GenInfo Identifier: | 46395991 |
NCBI Gene ID: | 85365 |
NCBI Accession: | Q9H553.1 |
UniProt Secondary Accession: | Q9H553,Q8NBX2, Q8NC39, A2A2Y0, |
UniProt Related Accession: | Q9H553 |
Molecular Weight: | 37,017 Da |
NCBI Full Name: | Alpha-1,3/1,6-mannosyltransferase ALG2 |
NCBI Synonym Full Names: | ALG2, alpha-1,3/1,6-mannosyltransferase |
NCBI Official Symbol: | ALG2 |
NCBI Official Synonym Symbols: | CDGIi; CMS14; NET38; CMSTA3; hALPG2 |
NCBI Protein Information: | alpha-1,3/1,6-mannosyltransferase ALG2 |
UniProt Protein Name: | Alpha-1,3/1,6-mannosyltransferase ALG2 |
UniProt Synonym Protein Names: | Asparagine-linked glycosylation protein 2 homolog; GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase; GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase |
Protein Family: | Alpha-1,3/1,6-mannosyltransferase |
UniProt Gene Name: | ALG2 |
UniProt Entry Name: | ALG2_HUMAN |