AK1 Antibody (PACO14014)
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주문- SKU:
- PACO14014
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | AK1 Antibody (PACO14014) |
Antibody SKU: | PACO14014 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human AK1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal muscle tissue, Primary antibody: PACO14014(AK1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
Background: | Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. |
Synonyms: | adenylate kinase 1 |
UniProt Protein Function: | AK1: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Defects in AK1 are the cause of hemolytic anemia due to adenylate kinase deficiency (HAAKD). Belongs to the adenylate kinase family. |
UniProt Protein Details: | Protein type:EC 2.7.4.6; Kinase, other; Nucleotide Metabolism - purine; EC 2.7.4.3 Chromosomal Location of Human Ortholog: 9q34.1 Cellular Component: cytoplasm; cytosol Molecular Function:adenylate kinase activity; nucleoside diphosphate kinase activity Biological Process: nucleobase, nucleoside and nucleotide interconversion; nucleoside diphosphate phosphorylation; nucleoside triphosphate biosynthetic process Disease: Adenylate Kinase Deficiency, Hemolytic Anemia Due To |
NCBI Summary: | This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] |
UniProt Code: | P00568 |
NCBI GenInfo Identifier: | 20178288 |
NCBI Gene ID: | 203 |
NCBI Accession: | P00568.3 |
UniProt Secondary Accession: | P00568,Q9BVK9, Q9UQC7, |
UniProt Related Accession: | P00568 |
Molecular Weight: | 21,635 Da |
NCBI Full Name: | Adenylate kinase isoenzyme 1 |
NCBI Synonym Full Names: | adenylate kinase 1 |
NCBI Official Symbol: | AK1 |
NCBI Official Synonym Symbols: | HTL-S-58j |
NCBI Protein Information: | adenylate kinase isoenzyme 1 |
UniProt Protein Name: | Adenylate kinase isoenzyme 1 |
UniProt Synonym Protein Names: | ATP-AMP transphosphorylase 1 |
Protein Family: | Adenylate kinase |
UniProt Gene Name: | AK1 |
UniProt Entry Name: | KAD1_HUMAN |
Antibodies |
Anti-AK1 Antibody (CAB1218) |
Anti-AK1 Antibody (CAB13460) |
AK1 Antibody (PACO03621) |
AK1 Antibody (PACO07660) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |