AGXT Antibody (PACO18536)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO18536
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | AGXT Antibody (PACO18536) |
Antibody SKU: | PACO18536 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human AGXT |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal liver tissue, hepg2 cells, Primary antibody: PACO18536(AGXT Antibody) at dilution 1/1050, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
Background: | Serine—pyruvate aminotransferase is an enzyme that in humans is encoded by the AGXT gene. This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1), also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract. |
Synonyms: | Alanine-glyoxylate aminotransferase |
UniProt Protein Function: | AGXT: Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1); also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - glycine, serine and threonine; EC 2.6.1.51; Transferase; Amino Acid Metabolism - alanine, aspartate and glutamate; Mitochondrial; Motility/polarity/chemotaxis; EC 2.6.1.44 Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: peroxisomal matrix; peroxisome Molecular Function:alanine-glyoxylate transaminase activity; amino acid binding; protein binding; protein homodimerization activity; protein self-association; pyridoxal phosphate binding; receptor binding; serine-pyruvate transaminase activity; transaminase activity Biological Process: glycine biosynthetic process, by transamination of glyoxylate; glyoxylate catabolic process; glyoxylate metabolic process; L-alanine catabolic process; L-cysteine catabolic process; proteasomal protein catabolic process Disease: Hyperoxaluria, Primary, Type I |
NCBI Summary: | This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008] |
UniProt Code: | P21549 |
NCBI GenInfo Identifier: | 134855 |
NCBI Gene ID: | 189 |
NCBI Accession: | P21549.1 |
UniProt Secondary Accession: | P21549,Q53QU6, |
UniProt Related Accession: | P21549 |
Molecular Weight: | 43010 Da |
NCBI Full Name: | Serine--pyruvate aminotransferase |
NCBI Synonym Full Names: | alanine-glyoxylate aminotransferase |
NCBI Official Symbol: | AGXT |
NCBI Official Synonym Symbols: | AGT; PH1; SPT; AGT1; SPAT; TLH6; AGXT1 |
NCBI Protein Information: | serine--pyruvate aminotransferase |
UniProt Protein Name: | Serine--pyruvate aminotransferase |
UniProt Synonym Protein Names: | Alanine--glyoxylate aminotransferase (EC:2.6.1.44); AGT |
Protein Family: | Serine--pyruvate aminotransferase |
UniProt Gene Name: | AGXT |
UniProt Entry Name: | SPYA_HUMAN |