AGTRAP Antibody (PACO15353)
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주문- SKU:
- PACO15353
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | AGTRAP Antibody (PACO15353) |
Antibody SKU: | PACO15353 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human AGTRAP |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO15353(AGTRAP Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15353(AGTRAP Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. |
Synonyms: | angiotensin II receptor-associated protein |
UniProt Protein Function: | AGTRAP: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 1p36.22 Cellular Component: cytoplasm; intracellular membrane-bound organelle; nucleoplasm Molecular Function:protein binding |
NCBI Summary: | This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q6RW13 |
NCBI GenInfo Identifier: | 71152303 |
NCBI Gene ID: | 57085 |
NCBI Accession: | Q6RW13.1 |
UniProt Secondary Accession: | Q6RW13,Q5SNV4, Q5SNV5, Q96AC0, Q96PL4, Q9NRW9, A8MVQ5 |
UniProt Related Accession: | Q6RW13 |
Molecular Weight: | 11,948 Da |
NCBI Full Name: | Type-1 angiotensin II receptor-associated protein |
NCBI Synonym Full Names: | angiotensin II receptor associated protein |
NCBI Official Symbol: | AGTRAP |
NCBI Official Synonym Symbols: | ATRAP |
NCBI Protein Information: | type-1 angiotensin II receptor-associated protein |
UniProt Protein Name: | Type-1 angiotensin II receptor-associated protein |
UniProt Synonym Protein Names: | AT1 receptor-associated protein |
Protein Family: | Type-1 angiotensin II receptor-associated protein |
UniProt Gene Name: | AGTRAP |
UniProt Entry Name: | ATRAP_HUMAN |