AGAP2 Antibody (PACO19465)
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주문- SKU:
- PACO19465
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | AGAP2 Antibody (PACO19465) |
Antibody SKU: | PACO19465 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human AGAP2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO19465(AGAP2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: PACO19465(AGAP2 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO19465(AGAP2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
Synonyms: | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 |
UniProt Protein Function: | CENTG1: a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins (GAPs). A GAP for ARF1 and ARF5. Two alternatively-spliced isoforms have been described. Isoform 1 is brain-specific, and isoform 2 is ubiquitously expressed, with highest levels in brain and heart. Isoform 1 participates to the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. Regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. The PH domains of isoforms 1 and 2 bind phospholipids, but they differentially regulate subcellular location. The PH domain of isoform 1 directs the protein to the nucleus, but the PH domain of isoform 2 directs it to the cytosol. |
UniProt Protein Details: | Protein type:GAPs; Motility/polarity/chemotaxis; Tumor suppressor; GAPs, ARF Chromosomal Location of Human Ortholog: 12q14.1 Cellular Component: membrane; mitochondrion; nucleolus; nucleus Molecular Function:protein binding Biological Process: negative regulation of neuron apoptosis; negative regulation of protein catabolic process |
NCBI Summary: | The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
UniProt Code: | Q99490 |
NCBI GenInfo Identifier: | 97535883 |
NCBI Gene ID: | 116986 |
NCBI Accession: | Q99490.2 |
UniProt Secondary Accession: | Q99490,O00578, Q548E0, Q8IWU3, A8K9F7, |
UniProt Related Accession: | Q99490 |
Molecular Weight: | 90,537 Da |
NCBI Full Name: | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 |
NCBI Synonym Full Names: | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 |
NCBI Official Symbol: | AGAP2 |
NCBI Official Synonym Symbols: | PIKE; GGAP2; CENTG1 |
NCBI Protein Information: | arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 |
UniProt Protein Name: | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 |
UniProt Synonym Protein Names: | Centaurin-gamma-1; Cnt-g1; GTP-binding and GTPase-activating protein 2; GGAP2; Phosphatidylinositol 3-kinase enhancer; PIKE |
Protein Family: | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein |
UniProt Gene Name: | AGAP2 |
UniProt Entry Name: | AGAP2_HUMAN |